Results 11 to 20 of about 80,646 (211)
BK Polyomavirus-Induced Nephropathy in Native Kidney
Cureus, 2023 BK polyomavirus has been well-studied as an opportunistic infection in immunocompromised kidney transplant patients. In the majority of the population, BK polyomavirus establishes a lifelong infection in renal tubular and uroepithelial cells; however, in an immunocompromised state, the virus can reactivate and can lead to BK polyomavirus-associated ...
Munjal, Ripudaman S +3 more
openaire +3 more sources
A highly potent human antibody neutralizing all serotypes of BK polyomavirus.
PLoS PathogensBK polyomavirus infection poses a significant risk to kidney transplant recipients. Reactivation of dormant virus in the transplanted kidney, triggered by immunosuppression, can lead to BK polyomavirus-associated nephropathy in up to 10% of transplants ...
Marcel Weber +12 more
doaj +3 more sources
The Lancet Infectious Diseases, 2003 Polyomavirus hominis 1, better known as BK virus (BKV), infects up to 90% of the general population. However, significant clinical manifestations are rare and limited to individuals with impaired immune functions. BKV has been associated with diverse entities such as haemorrhagic cystitis, ureteric stenosis, vasculopathy, pneumonitis, encephalitis ...
Hirsch HH, Steiger J
openaire +4 more sources
BK Polyomavirus in Solid Organ Transplantation [PDF]
American Journal of Transplantation, 2013 The human BK polyomavirus (BKV) is the major cause of polyomavirus-associated nephropathy (PyVAN) putting 1-15% of kidney transplant patients at risk of premature allograft failure, but is less common in other solid organ transplants. Because effective antiviral therapies are lacking, screening kidney transplant patients for BKV replication in urine ...
Hirsch, H. H., Randhawa, P.
openaire +5 more sources
The human polyomavirus BK: Potential role in cancer [PDF]
Journal of Cellular Physiology, 2005 AbstractIn human cancer, a role has been suggested for the human polyomavirus BK, primarily associated with tubulointerstitial nephritis and ureteric stenosis in renal transplant recipients, and with hemorrhagic cystitis in bone marrow transplant (BMT) recipients.
FIORITI, DANIELA +6 more
openaire +6 more sources
BK Polyomavirus and Transformation [PDF]
American Journal of Transplantation, 2011 The human BK polyomavirus (PyV) (BKV) was isolated from the urine of a kidney transplant patient with the initials B.K. after cells with nuclear atypia were noted in the urine in the diagnostic workup of an alloureter stenosis. Electron microscopy revealed intranuclear inclusions of nonenveloped viral particles of 40–45-nm diameter suggesting infection
Tina Dalianis, Hans H. Hirsch
openaire +5 more sources
Cytomegalovirus and polyomavirus BK posttransplant [PDF]
Nephrology Dialysis Transplantation, 2007 Virus replication and progression to disease in transplant patients is determined by patient-, graft- and virus-specific factors. This complex interaction is modulated by the net state of immunosuppression and its impact on virus-specific cellular immunity.
Adrian, Egli +8 more
openaire +3 more sources
Role of BK human polyomavirus in cancer [PDF]
Infectious Agents and Cancer, 2018 Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer.
Levican, Jorge +4 more
openaire +8 more sources
The Agnogene of the Human Polyomavirus BK Is Expressed [PDF]
Journal of Virology, 1998 ABSTRACT Primate polyomavirus genomes all contain an open reading frame at the 5′ end of the late coding region called the agnogene. A simian virus 40 agnoprotein with unknown functions has previously been demonstrated. We now show that a BK virus agnoprotein appears in the perinuclear area and cytoplasm late in the infectious cycle.
C H, Rinaldo, T, Traavik, A, Hey
openaire +2 more sources
Optimized amplification of BK polyomavirus in urine
Journal of Virological Methods, 2022 BK polyomavirus (BKPyV) is a ubiquitous pathogen that typically results in asymptomatic infection. However, in immunocompromised individuals, BKPyV viral shedding in the urine can reach 109 copies per mL. These high viral levels within urine provide ideal samples for next-generation sequencing to accurately determine BKPyV genotype and identify ...
Elizabeth A. Odegard +9 more
openaire +3 more sources