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BK polyomavirus: latency, reactivation, diseases and tumorigenesis
Frontiers in Cellular and Infection Microbiology, 2023 The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals.
Xianfeng Zhou +4 more
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Molecular Evaluation of BK Polyomavirus Nephropathy
American Journal of Transplantation, 2005 Understanding at a molecular level, the immunologic response of polyomavirus nephropathy (PVN), a critical cause of kidney graft loss, could lead to new targets for treatment and diagnosis. We undertook a transcriptional evaluation of kidney allograft biopsies from recipients with PVN or acute rejection (AR), as well as from recipients with stable ...
R B, Mannon +9 more
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Kaohsiung Journal of Medical Sciences, 2016 Previous studies regarding the prevention of BK viremia following renal transplantation with fluoroquinolone have yielded conflicting results. The purpose of this systematic review was to examine the evidence regarding the efficacy of fluoroquinolone in ...
Tu-Run Song +6 more
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Indian Journal of Transplantation, 2022 Purpose: Hemorrhagic cystitis (HC) which occurs in 9%–31% of recipients after hematopoietic stem cell transplantation (HSCT) is an important cause of morbidity and mortality.
Ayça Koca Yozgat +7 more
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BK Virus in Cancer Development
Current Issues in Pharmacy and Medical Sciences, 2018 Polyomavirus (PyV) was discovered by accident in 1950 in the course of describing an infectious factor causing multiple tumours in rodents. The term is derived from two Greek words: poly (many) and oma (tumour).
Pasternak Justyna +2 more
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Detection of Bk Polyomavirus Antigen in Patients with Acute Lymphoblastic Leukemia
Diyala Journal of Medicine, 2023 Background: BK polyomavirus that is acquired in early childhood as BKPyV is near ubiquitous in adults with a seroprevalence of >80%, it has been found as the main cause of hemorrhagic cystitis in hematopoietic stem cell transplantation patients, due to
Safa H Ali , +3 more
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BK Polyomavirus-Induced Nephropathy in Native Kidney
Cureus, 2023 BK polyomavirus has been well-studied as an opportunistic infection in immunocompromised kidney transplant patients. In the majority of the population, BK polyomavirus establishes a lifelong infection in renal tubular and uroepithelial cells; however, in an immunocompromised state, the virus can reactivate and can lead to BK polyomavirus-associated ...
Munjal, Ripudaman S +3 more
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Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination
Viruses, 2020 Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
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Evaluation of polyomavirus BK reactivation in lupus patients who underwent kidney transplantation
Microbiologia Medica, 2012 Background. A pathogenic role for polyomavirus BK in systemic lupus erythematosus (SLE) has been proposed, however no study evaluated the occurrence of BK replication in renal transplant recipients according to the underlying disease leading to ...
Cristina Costa +9 more
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Exposing the Molecular Machinery of BK Polyomavirus [PDF]
Structure, 2016 BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues' (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing development of therapeutic antibodies and vaccines targeting ...
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