Results 101 to 110 of about 7,381 (220)
Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 3, March 2026.This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang +10 more
wiley +1 more source
Polypharmacological strategies for infectious bacteria
Pharmacological ReviewsPolypharmacological approaches have significant potential for the treatment of various complex diseases, including infectious bacteria-related diseases. Actually, multitargeting agents can achieve better therapeutic effects and overcome the drawbacks of monotherapy.
Leitão, Miguel M. +4 more
openaire +2 more sources
Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 774-778, March 2026.Abstract Background Anticholinergic medications and botulinum neurotoxin injections are established treatments for dystonia, yet they carry potential side effects and practical challenges. Deep brain stimulation (DBS) is offered in case of poor response to these approaches.
Marcela A. Montiel +5 more
wiley +1 more source
PharmaceuticsBackground: Drug–drug interactions (DDIs) may occur when two or more drugs are taken together, leading to undesired side effects or potential synergistic effects.
Pablo Garcia-Acero +6 more
doaj +1 more source
Drugs and Drug CandidatesBackground: The growing recognition of shared molecular pathways and molecular signatures between cardiovascular diseases and cancer has motivated interest in exploring antihypertensive-associated chemical space for oncological applications. Concurrently,
Uche A. K. Chude-Okonkwo, Mokete Motente
doaj +1 more source
Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]
, 2018 Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V +15 more
core +2 more sources
SysNatMed: rational natural medicine discovery by systems genetics
Frontiers in PharmacologyBackgroundAlthough acknowledged as an important complement to modern medicine, the utility of natural medicine (NM) remains under-exploited. We aimed to develop a novel data-driven approach for natural medicine discovery.MethodsGWAS summary statistics of
Chang-Qing Ye +13 more
doaj +1 more source
Exploiting kinase polypharmacology for nerve regeneration
Neural Regeneration Research, 2016 The human central nervous system (CNS) has a markedly poor capacity for regenerating its axons following injury. This appears to be due to two main causes: 1) a developmentally regulated decline in regenerative capacity within mature CNS neurons, and 2) the presence of biological components that constitute barriers to axon regeneration (e.g., growth ...
Hassan Al-Ali +2 more
openaire +3 more sources
Molecular OncologyMicrotubule‐targeting agents represent one of the most successful classes of anticancer agents. However, the development of drug resistance and the appearance of adverse effects hamper their clinical implementation.
Yao‐Yu Hsieh +2 more
doaj +1 more source
Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning [PDF]
Additional file 1. The list of descriptor names, instructions on how to run the python script, the distribution plots for the important descriptors, the heat map of activities for the dense dataset, the structure of the over-represented scaffolds in the ...
Barbara Zdrazil +3 more
core +3 more sources