Results 111 to 120 of about 7,381 (220)

Historeceptomic fingerprints for drug-like compounds

Frontiers in Physiology, 2015
Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology). The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the ...
Evgeny eShmelkov, Arsen eGrigoryan, James eSwetnam, Junyang eXin, Doreen eTivon, Sergey eShmelkov, Sergey eShmelkov, Timothy eCardozo   +7 more
doaj   +1 more source

Representing high throughput expression profiles via perturbation barcodes reveals compound targets

, 2016
High throughput mRNA expression profiling can be used to characterize the response of cell culture models to perturbations such as pharmacologic modulators and genetic perturbations.
Filzen, Tracey, Hermes, Jeffrey, Kutchukian, Peter, Li, Jing, Tudor, Matthew   +4 more
core   +3 more sources

Developing multi-target therapeutics to fine-tune the evolutionary dynamics of the cancer ecosystem

Frontiers in Pharmacology, 2015
Lei eXie, Philip E Bourne
doaj   +1 more source

The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data [PDF]

, 2017

core   +1 more source

A novel systems pharmacology model for herbal medicine injection: a case using reduning injection [PDF]

, 2014

core   +1 more source

Editorial: New GPCR targets and modulators to treat CNS disorders

Frontiers in Molecular Neuroscience, 2022
Philippe De Deurwaerdère, Evgeni Ponimaskin, Abdeslam Chagraoui, Abdeslam Chagraoui, Giuseppe Di Giovanni, Giuseppe Di Giovanni   +5 more
doaj   +1 more source

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]

, 2017
Diamond, Michael S, et al,, Govero, Jennifer   +2 more
core   +2 more sources

Target Class Repurposing Across Membrane Transporter Families Provides Privileged Ligands to Address Specific and Undruggable Pharmacological Targets. [PDF]

ACS Pharmacol Transl Sci
Rafehi M, Tägl F, Arlt NS, Neif M, Stefan K, Ismail Al-Khalil W, Busch H, Möller M, König J, Namasivayam V, Stefan SM.   +10 more
europepmc   +1 more source

Multimodal out-of-distribution individual uncertainty quantification enhances binding affinity prediction for polypharmacology. [PDF]

Nat Mach Intell
Badkul A, Xie L, Zhang S, Xie L.
europepmc   +1 more source

Polypharmacology of anthelmintics at host and parasite ion channels. [PDF]

PLoS Pathog
Chan JD, Ericksen SS, Zamanian M.
europepmc   +1 more source