Results 11 to 20 of about 7,381 (220)
The Polypharmacological Effects of Cannabidiol
Molecules, 2023 Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753). This naturally occurring secondary metabolite does not induce intoxication or exhibit the characteristic profile of drugs of abuse from cannabis like Δ9 ...
Jorge Castillo-Arellano +3 more
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Advances in Computational Polypharmacology
Molecular Informatics, 2022 AbstractIn drug discovery, polypharmacology encompasses the use of small molecules with defined multi‐target activity and in vivo effects resulting from multi‐target engagement. Multi‐target compounds are often efficacious in the treatment of complex diseases involving target and pathway networks, but might also elicit unwanted side effects ...
Christian Feldmann, Jürgen Bajorath
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Design and Synthesis of Hsp90 Inhibitors with B‐Raf and PDHK1 Multi‐Target Activity
ChemistryOpen, 2021 The design of multi‐target ligands has become an innovative approach for the identification of effective therapeutic treatments against complex diseases, such as cancer.
Dr. Luca Pinzi +4 more
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Set-Theoretic Formalism for Treating Ligand-Target Datasets
Molecules, 2021 Data on ligand–target (LT) interactions has played a growing role in drug research for several decades. Even though the amount of data has grown significantly in size and coverage during this period, most datasets remain difficult to analyze because of ...
Gerald Maggiora, Martin Vogt
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MTLD, a Database of Multiple Target Ligands, the Updated Version
Molecules, 2017 Polypharmacology plays an important role in drug discovery and polypharmacology drug strategies provide a novel path in drug design. However, to develop a polypharmacology drug with the desired profile remains a challenge. Previously, we developed a free
Chao Chen +4 more
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Pharmacology Research & Perspectives, 2022 To interpret the relationship between the polypharmacology of dipeptidyl‐peptidase IV inhibitors (DPP4i) and their suspected adverse drug reaction (ADR) profiles using a national registry.
Lauren Jones, Alan M. Jones
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Molecules, 2022 Background: Despite research on the molecular bases of Alzheimer’s disease (AD), effective therapies against its progression are still needed. Recent studies have shown direct links between AD progression and neurovascular dysfunction, highlighting it as
Luis Daniel Goyzueta-Mamani +6 more
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Personalized medicine : the impact on chemistry [PDF]
, 2010 An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew +3 more
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Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis
Molecules, 2020 Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug resistant M. tuberculosis strains, which lead to the need of new more efficient drugs.
Giovanni Stelitano +2 more
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The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions [PDF]
, 2018 Accepted for publication in a future issue of Future Medicinal Chemistry.The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative ...
Blomberg N +6 more
core +2 more sources