Results 21 to 30 of about 7,381 (220)

Multitarget Drug Discovery and Polypharmacology [PDF]

ChemMedChem, 2016
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given
BOLOGNESI, MARIA LAURA, CAVALLI, ANDREA
openaire   +3 more sources

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data [version 1; referees: 3 approved, 1 approved with reservations]

F1000Research, 2017
There many possible types of drug-target interactions, because there are a surprising number of ways in which drugs and their targets can associate with one another.
Gerry Maggiora, Vijay Gokhale
doaj   +1 more source

The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

Molecules, 2022
The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug).
Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos   +6 more
doaj   +1 more source

Chemogenomics knowledgebased polypharmacology analyses of drug abuse related G-protein coupled receptors and their ligands [PDF]

, 2014
Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental factors that influence its development and manifestation.
Fang, C, Liu, H, Ouyang, Q, Su, W, Wang, L, Xie, XQ   +5 more
core   +1 more source

Identifying Promiscuous Compounds with Activity against Different Target Classes

Molecules, 2019
Compounds with multitarget activity are of high interest for polypharmacological drug discovery. Such promiscuous compounds might be active against closely related target proteins from the same family or against distantly related or unrelated targets ...
Christian Feldmann, Filip Miljković, Dimitar Yonchev, Jürgen Bajorath   +3 more
doaj   +1 more source

Piecing together aminergic polypharmacology. [PDF]

Cell Res
Neuropsychiatric medications are often designed to have affinity for multiple ligand-binding sites across different receptor types to increase therapeutic efficacy. In a recent paper in Cell, Chen and colleagues implement a flexible scaffold-based cheminformatics approach to design bi-target therapeutics for dementia-related psychosis.
Fordyce BA, Roth BL.
europepmc   +4 more sources

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network. [PDF]

, 2019
Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb ...
Chen, Jianxin, Gao, Zhuye, Hu, Xiaochen, Li, Peng, Liu, Baoyan, Peng, Yonghong, Wang, Ning, Xu, Hao, Yang, Kuo, Zhang, Runshun, Zhou, Xuezhong, Zhu, Qiang   +11 more
core   +1 more source

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]

, 2013
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Bailey H. H., Ballestrero A., Bellamy W. T., Betanzos-Lara S., Bozic I., Bushra Qamar, Carew J. S., Castonguay A., Chan J., Constantini P., Dai Y., Degterev A., Dindo D., Doroshow J. H., Dyke M. W. Van, Fagan V., Finnilä S., Frank J. E., Fu Y., Fu Y., Gaiddon C., Garbutcheon-Singh K. B., Hannon M. J., Hartinger C. G., Hileman E. A., Holbeck S., Huo H., Ian Hands-Portman, Isolda Romero-Canelón, Jessica M. Hearn, Jordan M. A., Jungwirth U., Kelland L., Kerr J. F., Kroemer G., Lazebnik Y. A., Liu Z., Liu Z., Liu Z., Lu J.-J., McKeage M. J., Millar A. W., Monneret C., Nagata S., Park G. Y., Paull K., Perchellet E. M., Peter J. Sadler, Petrelli A., Pittella F., Porteous C. M., Pracharova J., Purewal M., Rai S. S., Rixe O., Saraste A., Shoemaker R. H., Shoemaker R. H., Siddik Z., Sidler D., Tsutsui T., Türk D., Van den Bogert C., Zalacaín M., Zhang Y.-W., Zhe Liu, Zhou D.-F., Zhu Z.   +67 more
core   +1 more source

Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin

International Journal of Inflammation, 2018
Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation.
Franco Cavaleri
doaj   +1 more source

Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ

Biomolecules, 2020
Adiponectin is an adipocyte-derived cytokine having an insulin-sensitizing activity. During the phenotypic screening of secondary metabolites derived from the marine fungus Aspergillus terreus, a poly cyclin-dependent kinase (CDK) inhibitor butyrolactone
Sungjin Ahn, Dong Man Jang, Sung Chul Park, Seungchan An, Jongheon Shin, Byung Woo Han, Minsoo Noh   +6 more
doaj   +1 more source