Results 151 to 160 of about 54,552 (286)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, Volume 20, Issue 4, Page 1022-1040, April 2026.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (Dactylorhiza). [PDF]

New Phytol
Summary Hybridization and polyploidy are major drivers of plant diversification, often accompanied by shifts in gene expression and genome composition. Small RNAs (smRNAs) are thought to influence such genomic changes, particularly through their interactions with transposable elements (TEs).
Eriksson MC, Thornton M, Trucchi E, Wolfe TM, Balao F, Hedrén M, Paun O.   +6 more
europepmc   +2 more sources

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, Volume 13, Issue 22, 17 April 2026.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Drivers of insect herbivory resistance and tolerance to plant damage in the Brachypodium distachyon species complex

American Journal of Botany, Volume 113, Issue 4, April 2026.
Abstract Premise Insect herbivory is a major biotic factor shaping plant populations and driving the evolution of defensive traits. Polyploidy (whole‐genome duplication) often induces substantial phenotypic and genotypic changes that may affect species interactions, including herbivory.
Antonio J. Manzaneda, Luisa M. Martínez, Ana Fernández‐Ocaña, Teresa Salido, Pedro J. Rey   +4 more
wiley   +1 more source

Shaped by context: Evolutionary trajectories of desiccation tolerance in land plants

American Journal of Botany, Volume 113, Issue 4, April 2026.
Abstract Desiccation tolerance (DT), the ability to survive near‐complete cellular dehydration, is widespread in diaspores but rare in the vegetative tissues of land plants. The patchy and punctuated phylogenetic distribution of vegetative desiccation tolerance (VDT) suggests that the trait is both ancient and recurrent, yet the evolutionary ...
Rose A. Marks, R. Shawn Abrahams, Jenna T. B. Ekwealor   +2 more
wiley   +1 more source

Second Line Treatment Decision as Per Standard of Care or Foundation Medicine in Patients With Locally Advanced or Metastatic Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Molecular genetic profiling is crucial for treatment choice in patients with advanced non‐small cell lung cancer (NSCLC). The Lung‐ONE study aimed to determine the clinical utility of comprehensive genomic profile (CGP) tests, such as FoundationOne CDx or FoundationOne Liquid, in guiding second line therapy decisions for advanced ...
Federico Rojo, Enriqueta Felip, Oscar Juan Vidal, Rosario García Campelo, David Aguiar Bujanda, Josefa Terrasa Pons, Rafael López‐Castro, Antonio Calles, Alfredo Paredes Lario, Reyes Bernabé Caro, Isidoro Barneto Aranda, Luis García‐Palacios, Javier De Castro Carpeño   +12 more
wiley   +1 more source

Toward Sustainability: Intensification of Light‐Driven Whole Cell Biocatalysis

ChemBioChem, Volume 27, Issue 8, April 2026.
Whole‐cell, light‐driven biotransformations in photoautotrophic microorganisms offer the potential for higher atom economy by directly harnessing reducing equivalents and oxygen generated through natural photosynthesis. Current advances include the development of strains with improved growth rates and reactor designs that mitigate self‐shading ...
Lenny Malihan‐Yap, Pablo Domínguez de Maria, Robert Kourist   +2 more
wiley   +1 more source

Pan-genomics of polyploid crops: from complexity to breeding. [PDF]

Front Plant Sci
Naik YD, Thudi M, Kamal N, Egan AN, Janga MR, Puppala N.   +5 more
europepmc   +1 more source

A Beginner's How‐To Guide to Urban Population Genetics and Genomics

Ecology and Evolution, Volume 16, Issue 4, April 2026.
This guide provides practical methodologies for studying how urbanization drives evolutionary and ecological changes in species through population genetics and genomics, covering genetic markers, analytical tools, and spatial modeling approaches.
Elizabeth J. Carlen, Lindsay S. Miles, Kevin Aviles‐Rodriguez, Warren Booth   +3 more
wiley   +1 more source