Results 81 to 90 of about 35,135 (271)

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

Genome assembly of six polyploid potato genomes

, 2020
Genome assembly of polyploid plant genomes is a laborious task as they contain more than two copies of the genome, are often highly heterozygous with a high level of repetitive DNA. Next Generation genome sequencing data representing one Chilean and five
Anglin, Noelle L., Tai, H.H., Stromvik, M.V., Ellis, David, Kyriakidou, M.   +4 more
core   +1 more source

Lotus-fish co-culture reshapes pond microbiota and improves ecological stability relative to fish monoculture

Frontiers in Microbiology
IntroductionThe lotus-fish co-culture ponds (LP) is a widely applied integrated aquaculture system in China. However, research on the micro-ecology of aquaculture in lotus ponds is still insufficient.
Shandong Chen, Yan Miao, Jiayu Yin, Zexun Zhou, Ye Yuan, YunYun Liu, Yongchun Li, Lei Zeng, Chongqing Wang, Zhongyuan Shen, Zhongyuan Shen, Zhongyuan Shen, Wuhui Li, Wuhui Li, Wuhui Li   +14 more
doaj   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation [PDF]

, 2011
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is that the immune effector cells in
Hallberg, David
core   +1 more source

Molecular Phylogenetics of Seven Cyprinidae Distant Hybrid Lineages: Genetic Variation, 2nNCRC Convergent Evolution, and Germplasm Implications

Biology
Distant hybridization is key to trait innovation and speciation, with Cyprinidae hybrid phylogeny helping to clarify diversification mechanisms. Yet, a major gap persists in Cyprinidae studies: the stabilization mechanisms of interspecific distant hybrid
Ziyi Wang, Yaxian Sun, Ting Liao, Hui Zhong, Qianhong Gu, Kaikun Luo   +5 more
doaj   +1 more source

Mapping a Novel Black Spot Resistance Locus in the Climbing Rose Brite Eyes™ (‘RADbrite’)

Frontiers in Plant Science, 2018
Rose black spot, caused by Diplocarpon rosae, is one of the most devastating foliar diseases of cultivated roses (Rosa spp.). The globally distributed pathogen has the potential to cause large economic losses in the outdoor cultivation of roses ...
Jason D. Zurn, David C. Zlesak, Matthew Holen, James M. Bradeen, Stan C. Hokanson, Nahla V. Bassil   +5 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Genome analyses and breeding of polyploid crops

Polyploidization is a common and important evolutionary process in the plant kingdom. Compared with diploid plant species, the intricate genome architecture of polyploid plant species presents substantial challenges in applying multi-omics approaches for
Stein, N., Cheng, L., Zhou, Q., Huang, S., Bao, Z. ; https://orcid.org/, Lassois, L., Kong, Q.   +6 more
core   +1 more source

Error-prone polyploid mitosis during normal Drosophila development

, 2010
Endopolyploidy arises during normal development in many species when cells undergo endocycles—variant cell cycles in which DNA replicates but daughter cells do not form.
Donald T. Fox, Joseph G. Gall, Allan C. Spradling   +2 more
core   +1 more source