Results 101 to 110 of about 7,549 (220)

Chromosome Doubling Enhances Biomass and Carotenoid Content in Lycium chinense

open access: yesPlants
Lycium chinense, a type of medicinal and edible plant, is rich in bioactive compounds beneficial to human health. In order to meet the market requirements for the yield and quality of L.
Runan Zhang   +5 more
doaj   +1 more source

Development of an Agent‐Based Model to Investigate Durability of Factor IX Activity in Hemophilia B Patients Treated With Etranacogene Dezaparvovec

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Many currently approved gene therapies use adeno‐associated virus (AAV) to deliver DNA sequences encoding protein(s)‐of‐interest into cells. The AAV viral genome forms stable, circular DNA structures called episomes after entering the nuclei. Therapeutic proteins are then generated in vivo from transcription and translation of these episomes ...
Yuezhe Li   +7 more
wiley   +1 more source

Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4500-4527, July 2026.
ABSTRACT Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ‐specific control.
Dong An   +13 more
wiley   +1 more source

An Efficient Method of Tetraploid and Octaploid Induction in Arabidopsis thaliana Using Colchicine Treatment

open access: yes, 2021
Colchicine gel treatment is one of the major methods used to induce polyploid strains in plants. In this study, we examined several conditions of colchicine gel treatment in the diploid and tetraploid of Arabidopsis thaliana (ecotype: Columbia) to ...
岩元, 明敏, 菊池, 涼夏
core  

Single‐Cell CRISPR: An Efficient Strategy for Decoding Plant Cis‐Regulatory Complexity

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4454-4467, July 2026.
ABSTRACT The generation of complex traits involves the coordinated interplay of multiple gene networks. Elucidating the function of transcriptional cis‐regulatory elements (CREs) in regulating gene expression is crucial for understanding complex regulatory pathways and improving our ability to modify macro‐phenotypes.
Yuanhang Zhang   +5 more
wiley   +1 more source

Session 2B: Polyploid Hepatocytes and Implications for Liver Cancer

open access: yes, 2018
Around 50% of human liver cells and 90% of mouse liver cells are polyploid, containing more than two sets of chromosomes. However, polyploidy’s relationship to liver cancer is not yet known.
Chen, Maelee
core  

CRISPR/Cas‐Mediated Gene Editing in Plant Immunity and Its Potential for the Future Development of Fungal, Oomycete, and Bacterial Pathogen‐Resistant Pulse Crops

open access: yesPlant, Cell &Environment, Volume 49, Issue 7, Page 3573-3585, July 2026.
ABSTRACT Pulses provide myriad health benefits and are advantageous in an environmental context as a result of their leguminous nature. However, phytopathogenic fungi, oomycetes and bacteria pose a substantial threat to pulse production, at times leading to crop failure.
Stacy D. Singer   +6 more
wiley   +1 more source

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

open access: yes, 2011
Induction of 2n pollen is a required technique for cultivating polyploid via sexual polyploidy. Orthogonal design or Taguchi Design was applied to select the best treatment process of 2n pollen induction inPopulus×popularisfrom different levels of the ...
D. Li   +6 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, Volume 13, Issue 35, 24 June 2026.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.

open access: yes, 2014
The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell repopulation during tumor relapse.
Carla Jimenez (578640)   +21 more
core   +1 more source

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