Results 1 to 10 of about 10,278 (119)

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Cell Reports, 2021
Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Michael Regnier, Anthony Pettinato, Jennifer J VanOudenhove   +2 more
exaly   +3 more sources

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity

Platelets, 2022
Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and maturation of
Lanyue Hu, Weiwei Zhang, Zheng Xiang, Yali Wang, Cheng Zeng, Xiaojie Wang, Chengning Tan, Yichi Zhang, Fengjie Li, Yanni Xiao, Luping Zhou, Jiuxuan Li, Chun Wu, Yang Xiang, Lixin Xiang, Xiaomei Zhang, Xueying Wang, Wuchen Yang, Maoshan Chen, Qian Ran, Zhongjun Li, Li Chen   +21 more
doaj   +1 more source

Increasing the value of plant raw material by inducing genomic changes. Past and prospects for the varietal progress of medicinal plants [PDF]

Herba Polonica, 2023
The value of herbal raw material guarantees the success of phytotherapy. However, the quality of raw material depends on many complex factors. This is a particular challenge in the era of climate changes.
Marcin Ożarowski, Aleksandra Deja, Anna Forycka, Ryszard Słomski   +3 more
doaj   +1 more source

Integrative analyses of targeted metabolome and transcriptome of Isatidis Radix autotetraploids highlighted key polyploidization-responsive regulators

BMC Genomics, 2021
Background Isatidis Radix, the root of Isatis indigotica Fort. (Chinese woad) can produce a variety of efficacious compound with medicinal properties. The tetraploid I.
Zixuan Zhang, Mingpu Tan, Yingying Zhang, Yue Jia, Shuxian Zhu, Jiang Wang, Jiajing Zhao, Yueyue Liao, Zengxu Xiang   +8 more
doaj   +1 more source

Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines. [PDF]

PLoS ONE, 2014
Megakaryocytes (MKs) are one of the few cell types that become polyploid; however, the mechanisms by which these cells are designated to become polyploid are not fully understood.
Chang-Ling Li, Jin-Gang Yang, Di Lin, Yong-Shan Zhao, Shuo Liu, Si-Ning Xing, Song Zhao, Cong-Qin Chen, Zhi-Ming Jiang, Fei-Fei Pu, Jian-Ping Cao, Dong-Chu Ma   +11 more
doaj   +1 more source

Ornamental plant breeding: entering a new era?

Ornamental Horticulture, 2022
During the last century, plant breeding of crops and ornamentals has become an important business. Mendel’s principles of inheritance of traits laid the foundation of today’s modern genetics.
Johan Van Huylenbroeck, Krishna Bhattarai   +1 more
doaj   +1 more source

Comparative Analysis Reveals Different Evolutionary Fates and Biological Functions in Wheat Duplicated Genes (Triticum aestivum L.)

Plants, 2023
Wheat (Triticum aestivum L.) is a staple food crop that provides 20% of total human calorie consumption. Gene duplication has been considered to play an important role in evolution by providing new genetic resources.
Licao Cui, Hao Cheng, Zhe Yang, Chuan Xia, Lichao Zhang, Xiuying Kong   +5 more
doaj   +1 more source

Nano‐Strainer: A workflow for the identification of single‐copy nuclear loci for plant systematic studies, using target capture kits and Oxford Nanopore long reads

Ecology and Evolution, 2023
In modern plant systematics, target enrichment enables simultaneous analysis of hundreds of genes. However, when dealing with reticulate or polyploidization histories, few markers may suffice, but often are required to be single‐copy, a condition that is
Agnes Scheunert, Ulrich Lautenschlager, Tankred Ott, Christoph Oberprieler   +3 more
doaj   +1 more source

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease

Journal of Developmental Biology, 2023
Whole genome duplication (WGD) or polyploidization can occur at the cellular, tissue, and organismal levels. At the cellular level, tetraploidization has been proposed as a driver of aneuploidy and genome instability and correlates strongly with cancer ...
Mara Schvarzstein, Fatema Alam, Muhammad Toure, Judith L. Yanowitz   +3 more
doaj   +1 more source

Megakaryocyte polyploidization: role in platelet production

Platelets, 2020
Mammal megakaryocytes (MK) undergo polyploidization during their differentiation. This process leads to a marked increase in the MK size and of their cytoplasm.
William Vainchenker, Hana Raslova
doaj   +1 more source