Results 11 to 20 of about 12,812 (219)

Megakaryocyte polyploidization: role in platelet production

Platelets, 2020
Mammal megakaryocytes (MK) undergo polyploidization during their differentiation. This process leads to a marked increase in the MK size and of their cytoplasm.
William Vainchenker, Hana Raslova
doaj   +2 more sources

Functional Reprogramming of Polyploidization in Megakaryocytes [PDF]

Developmental Cell, 2015
Polyploidization is a natural process that frequently accompanies differentiation; its deregulation is linked to genomic instability and cancer. Despite its relevance, why cells select different polyploidization mechanisms is unknown. Here we report a systematic genetic analysis of endomitosis, a process in which megakaryocytes become polyploid by ...
Trakala, Marianna, Rodríguez-Acebes, Sara, Maroto, María, Symonds, Catherine E, Santamaria, David, Malumbres, Marcos, Ortega Jimenez, Sagrario, Barbacid, Mariano, Mendez, Juan, Malumbres Martinez, Marcos   +9 more
openaire   +5 more sources

Atypical E2f functions are critical for pancreas polyploidization. [PDF]

PLoS ONE, 2018
The presence of polyploid cells in the endocrine and exocrine pancreas has been reported for four decades. In rodents, pancreatic polyploidization is initiated after weaning and the number of polyploid cells increases with age. Surprisingly the molecular
Ramadhan B Matondo, Eva Moreno, Mathilda J M Toussaint, Peter C J Tooten, Saskia C van Essen, Elsbeth A van Liere, Sameh A Youssef, Laura Bongiovanni, Alain de Bruin   +8 more
doaj   +6 more sources

Polyploidization in Liver Tissue

The American Journal of Pathology, 2014
Polyploidy (alias whole genome amplification) refers to organisms containing more than two basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago, and it is known that such processes occur in many eukaryotes under a variety of circumstances.
Gentric, Géraldine, Desdouets, Chantal
openaire   +5 more sources

Somatic genome-doubling is the most parsimonious route to allopolyploidy. [PDF]

New Phytol
Summary The origin of a polyploid can hinge on a single errant cell division, a mistake in the cell cycle that leads to genome‐doubling and re‐writes the rules of chromosome pairing and segregation. In plants, the evolutionary significance of these errors is magnified by lack of an early sequestered germline, meaning somatic mutations can be heritable.
Burns R, Scott AD, Novikova PY.
europepmc   +2 more sources

Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high-throughput RNA sequencing. [PDF]

Plant Genome
Abstract Polyploidization has played a key role in plant genome evolution. Eragrostis curvula (Schrad.) Ness, a perennial forage grass species of the Poaceae family, is an excellent model for investigating genome duplication due to its natural variation in ploidy levels.
Santoro DF, Carballo J, Pasten MC, Gallo CA, Albertini E, Echenique V.   +5 more
europepmc   +2 more sources

Inhibition of polyploidization in Pten-deficient livers reduces steatosis [PDF]

, 2022
The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver-specific deletion of Pten in mice results in the hyper-activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid
Eva Moreno, Moreno, Eva, van Essen, Saskia C, Westendorp, Bart, Bongiovanni, Laura, Martijn R. Molenaar, Laura Bongiovanni, van de Lest, Chris H. A., Mathilda J. M. Toussaint, Martin Houweling, Matondo, Augustine B, Matondo, Augustine B., Houweling, Martin, Helms, J. Bernd, Saskia C. van Essen, Helms, J Bernd, J. Bernd Helms, Molenaar, Martijn R, Toussaint, Mathilda J. M., de Bruin, Alain, Bart Westendorp, van de Lest, Chris H A, Augustine B. Matondo, Chris H. A. van de Lest, Molenaar, Martijn R., van Essen, Saskia C., Toussaint, Mathilda J M, Alain de Bruin   +27 more
core   +2 more sources

Comparative Analysis Reveals Different Evolutionary Fates and Biological Functions in Wheat Duplicated Genes (Triticum aestivum L.)

Plants, 2023
Wheat (Triticum aestivum L.) is a staple food crop that provides 20% of total human calorie consumption. Gene duplication has been considered to play an important role in evolution by providing new genetic resources.
Licao Cui, Hao Cheng, Zhe Yang, Chuan Xia, Lichao Zhang, Xiuying Kong   +5 more
doaj   +1 more source

Priors for Genotyping Polyploids [PDF]

Bioinformatics, 2019
Abstract Motivation Empirical Bayes techniques to genotype polyploid organisms usually either (i) assume technical artifacts are known a priori or (ii) estimate technical artifacts simultaneously with the prior genotype distribution.
Gerard, David, Ferrão, Luís Felipe Ventorim   +1 more
openaire   +2 more sources

Nano‐Strainer: A workflow for the identification of single‐copy nuclear loci for plant systematic studies, using target capture kits and Oxford Nanopore long reads

Ecology and Evolution, 2023
In modern plant systematics, target enrichment enables simultaneous analysis of hundreds of genes. However, when dealing with reticulate or polyploidization histories, few markers may suffice, but often are required to be single‐copy, a condition that is
Agnes Scheunert, Ulrich Lautenschlager, Tankred Ott, Christoph Oberprieler   +3 more
doaj   +1 more source