Results 11 to 20 of about 3,888 (165)

Proteomic characterization and cytotoxic potential of proteins from Cuscuta (Cuscuta epithymum (L.) crude herbal product against MCF-7 human breast cancer cell line [PDF]

BMC Complementary Medicine and Therapies
Background The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals that exhibit ...
Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed   +6 more
doaj   +2 more sources

Polyribonucleotide nucleotidyltransferase 1 (PNPT1; PNPASE) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

Scientific Reports, 2016
The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase.
Carina C De Oliveira Mann, Gregor Witte, Karl-peter Hopfner   +2 more
exaly   +2 more sources

Mitochondrial RNA maturation. [PDF]

RNA Biol
\ua9 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The vast majority of oxygen-utilizing eukaryotes need to express their own mitochondrial genome, mtDNA, to survive.
Chrzanowska-Lightowlers ZM, Lightowlers RN.   +1 more
europepmc   +3 more sources

Multilayered proteomics reveals that JAM-A promotes breast cancer progression via regulation of amino acid transporter LAT1. [PDF]

Cancer Sci
We uncovered junctional adhesion molecule‐A (JAM‐A), one of the transmembrane‐type tight junction proteins (TJPs), promoted breast cancer progression via regulation of amino acid transporter LAT1 using multilayered proteomics. Our findings provide a new insight into a therapeutic strategy, JAM‐A‐targeted therapy ideally combined with LAT1‐targeted ...
Magara K, Takasawa A, Takasawa K, Aoyama T, Ota M, Kyuno D, Ono Y, Murakami T, Yamamoto S, Nakamori Y, Nakahashi N, Kutomi G, Takemasa I, Hasegawa T, Osanai M.   +14 more
europepmc   +2 more sources

High-quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures. [PDF]

Microbiologyopen
In this study, the genome of a new thermophilic cyanobacterium, Thermosynechococcaceae cyanobacterium sp. Okahandja, isolated from a hot spring near Okahandja in Namibia, was sequenced. Additionally, cultivations were conducted at elevated temperatures of 40, 50, and 55°C, followed by analyses of the respective adapted proteomes based on the annotated ...
Arnold ND, Paper M, Fuchs T, Ahmad N, Jung P, Lakatos M, Rodewald K, Rieger B, Qoura F, Kandawa-Schulz M, Mehlmer N, Brück TB.   +11 more
europepmc   +2 more sources

Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies [PDF]

, 2022
The genetic interferonopathies are a heterogeneous group of disorders thought to be caused by the dysregulated expression of interferons and are now commonly considered in the differential diagnosis of children presenting with recurrent or persistent ...
Benjamin, P, Boddaert, N, Carney, O, D'Arco, F, Eleftheriou, D, Hemingway, C, Lobel, U, Mankad, K, Roux, C-J, Sudhakar, S   +9 more
core   +1 more source

Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells

FEBS Open Bio, Volume 13, Issue 2, Page 323-340, February 2023., 2023
LRP/LR is overexpressed in many cancer cell types and is associated with various cancer‐promoting processes. In this study, we downregulated LRP/LR in lung cancer cells and showed that this strategy has a four‐fold function in impeding key cancer hallmarks in the lung cancer cells, which therefore has the potential for improving the prognosis of those ...
Monique J. Bignoux, Tyrone C. Otgaar, Martin Bernert, Stefan F. T. Weiss, Eloise Ferreira   +4 more
wiley   +1 more source

MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells

Current Medical Science, 2022
It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer (BC). Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1 (PNPT1) is a pivotal mediator involved in RNA decay and cell apoptosis ...
Qing-gang Hu, Zhi Yang, Jia-wei Chen, Gallina Kazobinka, L. Tian, Wen-cheng Li   +5 more
semanticscholar   +1 more source

Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25

Annals of Neurology, Volume 92, Issue 1, Page 122-137, July 2022., 2022
Objective Dominant spinocerebellar ataxias (SCA) are characterized by genetic heterogeneity. Some mapped and named loci remain without a causal gene identified. Here we applied next generation sequencing (NGS) to uncover the genetic etiology of the SCA25 locus.
Mathieu Barbier, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M. Tankard, Claire Ewenczyk, Kayli C. Davies, Patricia Lino‐Coulon, Claire Colace, Haloom Rafehi, Nicolas Auger, Brendan R. E. Ansell, Ivo van der Stelt, Katherine B. Howell, Marie Coutelier, David J. Amor, Emeline Mundwiller, Lena Guillot‐Noël, Elsdon Storey, R. J. McKinlay Gardner, Mathew J. Wallis, Alfredo Brusco, Olga Corti, Agnès Rötig, Richard J. Leventer, Alexis Brice, Martin B. Delatycki, Giovanni Stevanin, Paul J. Lockhart, Alexandra Durr   +29 more
wiley   +1 more source