Results 11 to 20 of about 3,251 (110)

cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B. [PDF]

FASEB J
Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate ...
Montano MM, Yeh IJ, Ketchart W.
europepmc   +3 more sources

Isolation of <i>Synechocystis</i> Mutants Overproducing Mannitol Directly from CO₂ via Laboratory Evolution under Increasing Salt Concentration. [PDF]

ACS Synth Biol
Mannitol is a naturally occurring C(6) polyol with a wide range of applications in the food and pharmaceutical industry. In a previous study, mannitol production was achieved via the direct conversion of CO2 in Synechocystis sp. PCC6803. However, a major
Wu W, Jongbloets JA, Du W, Hellingwerf KJ, Branco Dos Santos F.   +4 more
europepmc   +2 more sources

Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis [PDF]

npj Biofilms and Microbiomes
Peri-implantitis is a severe biofilm-associated infection affecting millions worldwide. This cross-sectional study aimed to identify taxonomic and functional biomarkers that reliably indicate peri-implantitis by utilizing paired data from full length 16S
Amruta A. Joshi, Szymon P. Szafrański, Matthias Steglich, Ines Yang, Taoran Qu, Paula Schaefer-Dreyer, Xing Xiao, Wiebke Behrens, Jasmin Grischke, Susanne Häussler, Meike Stiesch   +10 more
doaj   +2 more sources

Involvement of RNase J in CRISPR RNA maturation in the cyanobacterium <i>Synechocystis</i> sp. PCC 6803. [PDF]

Microlife
Many bacteria and archaea use CRISPR-Cas systems, which provide RNA-based, adaptive, and inheritable immune defenses against invading viruses and other foreign genetic elements. The proper processing of CRISPR guide RNAs (crRNAs) is a crucial step in the
Bilger R, Drepper F, Knapp B, Berndt T, Landerer H, Putzer H, Huesgen PF, Hess WR.   +7 more
europepmc   +2 more sources

Proteomic characterization and cytotoxic potential of proteins from Cuscuta (Cuscuta epithymum (L.) crude herbal product against MCF-7 human breast cancer cell line [PDF]

BMC Complementary Medicine and Therapies
Background The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals that exhibit ...
Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed   +6 more
doaj   +2 more sources

Polyribonucleotide nucleotidyltransferase 1 (PNPT1; PNPASE) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells

FEBS Open Bio, Volume 13, Issue 2, Page 323-340, February 2023., 2023
LRP/LR is overexpressed in many cancer cell types and is associated with various cancer‐promoting processes. In this study, we downregulated LRP/LR in lung cancer cells and showed that this strategy has a four‐fold function in impeding key cancer hallmarks in the lung cancer cells, which therefore has the potential for improving the prognosis of those ...
Monique J. Bignoux, Tyrone C. Otgaar, Martin Bernert, Stefan F. T. Weiss, Eloise Ferreira   +4 more
wiley   +1 more source

Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25

Annals of Neurology, Volume 92, Issue 1, Page 122-137, July 2022., 2022
Objective Dominant spinocerebellar ataxias (SCA) are characterized by genetic heterogeneity. Some mapped and named loci remain without a causal gene identified. Here we applied next generation sequencing (NGS) to uncover the genetic etiology of the SCA25 locus.
Mathieu Barbier, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M. Tankard, Claire Ewenczyk, Kayli C. Davies, Patricia Lino‐Coulon, Claire Colace, Haloom Rafehi, Nicolas Auger, Brendan R. E. Ansell, Ivo van der Stelt, Katherine B. Howell, Marie Coutelier, David J. Amor, Emeline Mundwiller, Lena Guillot‐Noël, Elsdon Storey, R. J. McKinlay Gardner, Mathew J. Wallis, Alfredo Brusco, Olga Corti, Agnès Rötig, Richard J. Leventer, Alexis Brice, Martin B. Delatycki, Giovanni Stevanin, Paul J. Lockhart, Alexandra Durr   +29 more
wiley   +1 more source

Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome

Journal of Inherited Metabolic Disease, Volume 45, Issue 2, Page 292-307, March 2022., 2022
Abstract SUPV3L1 encodes a helicase that is mainly localized in the mitochondria. It has been shown in vitro to possess both double‐stranded RNA and DNA unwinding activity that is ATP‐dependent. Here we report the first two patients for this gene who presented with a homozygous preliminary stop codon resulting in a C‐terminal truncation of the SUPV3L1 ...
Selma L. van Esveld, Richard J. Rodenburg, Fathiya Al‐Murshedi, Eiman Al‐Ajmi, Sana Al‐Zuhaibi, Martijn A. Huynen, Johannes N. Spelbrink   +6 more
wiley   +1 more source

Comparative genomics provides structural and functional insights into Bacteroides RNA biology

Molecular Microbiology, Volume 117, Issue 1, Page 67-85, January 2022., 2022
Most of our knowledge of bacterial regulatory RNAs and their associated proteins stems from model organisms such as Escherichia coli and Salmonella enterica. In contrast, the RNA biology of Bacteroides spp.—an important component of the human gut microbiota—is significantly understudied.
Gianluca Prezza, Daniel Ryan, Gohar Mädler, Sarah Reichardt, Lars Barquist, Alexander J. Westermann   +5 more
wiley   +1 more source