Results 31 to 40 of about 3,251 (110)

Predicted Cold Shock Proteins from the Extremophilic Bacterium Deinococcus maricopensis and Related Deinococcus Species

International Journal of Microbiology, Volume 2017, Issue 1, 2017., 2017
While many studies have examined the mechanisms by which extremophilic Deinococci survive exposure to ionizing radiation, very few publications have characterized the cold shock adaptations of this group, despite many species being found in persistent cold environments and environments prone to significant daily temperature fluctuations. Bacterial cold
Michael J. LaGier, Todd R. Callaway
wiley   +1 more source

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature Communications, 2023
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu, B. Usher, C. Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, O. Neyrolles, T. R. Blower, P. Genevaux   +9 more
semanticscholar   +1 more source

Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells

Journal of Ophthalmology, Volume 2017, Issue 1, 2017., 2017
Purpose. To investigate the effect of rho kinase inhibitors on oxidative stress in trabecular meshwork (TM) cells. Methods. TM cells were isolated from the eyes of cynomolgus monkeys. Y‐27632 and menadione were used to inhibit rho kinase and induce production of reactive oxygen species (ROS), respectively.
Tomokazu Fujimoto, Toshihiro Inoue, Saori Ohira, Nanako Awai-Kasaoka, Takanori Kameda, Miyuki Inoue-Mochita, Hidenobu Tanihara, Ciro Costagliola   +7 more
wiley   +1 more source

ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia

Microbiology spectrum, 2023
The emergence, evolution, and worldwide spread of antibiotic resistance present a significant global public health crisis. For aminoglycoside antibiotics, enzymatic drug modification is the most common mechanism of resistance.
Xiu-sheng Sheng, Wei Lu, Aifang Li, Junwan Lu, Chunhan Song, Jiefen Xu, Youming Dong, Chunqing Fu, Xi Lin, Mei Zhu, Qiyu Bao, Kewei Li   +11 more
semanticscholar   +1 more source

High‐quality genome of a novel Thermosynechococcaceae species from Namibia and characterization of its protein expression patterns at elevated temperatures

MicrobiologyOpen, Volume 13, Issue 5, October 2024.
In this study, the genome of a new thermophilic cyanobacterium, Thermosynechococcaceae cyanobacterium sp. Okahandja, isolated from a hot spring near Okahandja in Namibia, was sequenced. Additionally, cultivations were conducted at elevated temperatures of 40, 50, and 55°C, followed by analyses of the respective adapted proteomes based on the annotated ...
Nathanael D. Arnold, Michael Paper, Tobias Fuchs, Nadim Ahmad, Patrick Jung, Michael Lakatos, Katia Rodewald, Bernhard Rieger, Farah Qoura, Martha Kandawa‐Schulz, Norbert Mehlmer, Thomas B. Brück   +11 more
wiley   +1 more source

Microarray Analysis of the Juvenile Hormone Response in Larval Integument of the Silkworm, Bombyx mori

International Journal of Genomics, Volume 2014, Issue 1, 2014., 2014
Juvenile hormone (JH) coordinates with 20‐hydroxyecdysone (20E) to regulate larval growth and molting in insects. However, little is known about how this cooperative control is achieved during larval stages. Here, we induced silkworm superlarvae by applying the JH analogue (JHA) methoprene and used a microarray approach to survey the mRNA expression ...
Daojun Cheng, Jian Peng, Meng Meng, Ling Wei, Lixia Kang, Wenliang Qian, Qingyou Xia, Prabhakara V. Choudary   +7 more
wiley   +1 more source

Identification and characterization of a novel aminoglycoside O-nucleotidyltransferase ANT(6)-If from Paenibacillus thiaminolyticus PATH554

Frontiers in Microbiology, 2023
Background Paenibacillus thiaminolyticus, a species of genus Paenibacillus of the family Paenibacillaceae, exists widely in environments and habitats in various plants and worms, and occasionally causes human infections.
Junwan Lu, Yu-Fen Sha, Mengdi Gao, Weina Shi, Xi Lin, Kewei Li, Qiyu Bao, Chunling Feng   +7 more
semanticscholar   +1 more source

Multilayered proteomics reveals that JAM‐A promotes breast cancer progression via regulation of amino acid transporter LAT1

Cancer Science, Volume 115, Issue 9, Page 3153-3168, September 2024.
We uncovered junctional adhesion molecule‐A (JAM‐A), one of the transmembrane‐type tight junction proteins (TJPs), promoted breast cancer progression via regulation of amino acid transporter LAT1 using multilayered proteomics. Our findings provide a new insight into a therapeutic strategy, JAM‐A‐targeted therapy ideally combined with LAT1‐targeted ...
Kazufumi Magara, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Misaki Ota, Daisuke Kyuno, Yusuke Ono, Taro Murakami, Soh Yamamoto, Yuna Nakamori, Naoya Nakahashi, Goro Kutomi, Ichiro Takemasa, Tadashi Hasegawa, Makoto Osanai   +14 more
wiley   +1 more source

Expanding the Substrate Scope of a Bacterial Nucleotidyltransferase via Allosteric Mutations.

ACS Infectious Diseases, 2022
Bacterial glycoconjugates, such as cell surface polysaccharides and glycoproteins, play important roles in cellular interactions and survival. Enzymes called nucleotidyltransferases use sugar-1-phosphates and nucleoside triphosphates (NTPs) to produce ...
Maggie C Zheng, Meng Zheng, T. Lupoli
semanticscholar   +1 more source

Genetic dissection of domestication traits in interspecific chickpea populations

The Plant Genome, Volume 17, Issue 1, March 2024.
Abstract Chickpea (Cicer arietinum) is a pulse crop that provides an integral source of nutrition for human consumption. The close wild relatives Cicer reticulatum and Cicer echinospermum harbor untapped genetic diversity that can be exploited by chickpea breeders to improve domestic varieties.
Toby E. Newman, Silke Jacques, Christy Grime, Fredrick M. Mobegi, Fiona L. Kamphuis, Yuphin Khentry, Robert Lee, Lars G. Kamphuis   +7 more
wiley   +1 more source