Results 41 to 50 of about 5,329 (170)

Utilization of glycosaminoglycans by the human gut microbiota: participating bacteria and their enzymatic machineries

Gut Microbes, 2022
Glycosaminoglycans (GAGs) are consistently present in the human colon in free forms and as part of proteoglycans. Their utilization is critical for the colonization and proliferation of gut bacteria and also the health of hosts. Hence, it is essential to
Parkash Singh Rawat, Ahkam Saddam Seyed Hameed, Xiangfeng Meng, Weifeng Liu   +3 more
doaj   +1 more source

Analysis of the bovine rumen microbiome reveals a diversity of Sus-like polysaccharide utilization loci from the bacterial phylum Bacteroidetes [PDF]

Journal of Industrial Microbiology and Biotechnology, 2014
Abstract Several unique Sus-like polysaccharide utilization loci (PULs) were identified from bacteria resident in bovine rumen microbiomes through functional screening of a fosmid library. The loci were phylogenetically assigned to the genus Prevotella within the phylum Bacteroidetes.
Rosewarne, Carly P., Pope, Phillip B., Cheung, Jane L., Morrison, Mark   +3 more
openaire   +6 more sources

Bacteroidetes use thousands of enzyme combinations to break down glycans

Nature Communications, 2019
Bacteroidetes genomes contain polysaccharide utilization loci (PULs), each of which encodes enzymes for the breakdown of one particular glycan. By analyzing the enzyme composition of 13,537 PULs, the authors suggest that the natural glycan diversity is ...
Pascal Lapébie, Vincent Lombard, Elodie Drula, Nicolas Terrapon, Bernard Henrissat   +4 more
doaj   +1 more source

Adaptations of Alteromonas sp. 76-1 to Polysaccharide Degradation: A CAZyme Plasmid for Ulvan Degradation and Two Alginolytic Systems

Frontiers in Microbiology, 2019
Studying the physiology and genomics of cultured hydrolytic bacteria is a valuable approach to decipher the biogeochemical cycling of marine polysaccharides, major nutrients derived from phytoplankton and macroalgae.
Hanna Koch, Heike M. Freese, Richard L. Hahnke, Meinhard Simon, Matthias Wietz   +4 more
doaj   +1 more source

Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides

mBio, 2020
The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition, which are fueled primarily by the metabolism of otherwise indigestible complex carbohydrates commonly known as dietary fiber.
Guillaume Déjean, Kazune Tamura, Adriana Cabrera, Namrata Jain, Nicholas A. Pudlo, Gabriel Pereira, Alexander Holm Viborg, Filip Van Petegem, Eric C. Martens, Harry Brumer   +9 more
doaj   +1 more source

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

mBio
The human colon hosts hundreds of commensal bacterial species, many of which ferment complex dietary carbohydrates. To transform these fibers into metabolically accessible compounds, microbes often express a series of dedicated enzymes homologous to the ...
Jeremy P. H. Wong, Noémie Chillier, Michaela Fischer-Stettler, Samuel C. Zeeman, Tom J. Battin, Alexandre Persat   +5 more
doaj   +1 more source

Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization

Cell Reports, 2023
Summary: To understand how a bacterium ultimately succeeds or fails in adapting to a new host, it is essential to assess the temporal dynamics of its fitness over the course of colonization.
Megan S. Kennedy, Manjing Zhang, Orlando DeLeon, Jacie Bissell, Florian Trigodet, Karen Lolans, Sara Temelkova, Katherine T. Carroll, Aretha Fiebig, Adam Deutschbauer, Ashley M. Sidebottom, Joash Lake, Chris Henry, Phoebe A. Rice, Joy Bergelson, Eugene B. Chang   +15 more
doaj   +1 more source

Research Progress on the Metabolic Plasticity and Regulatory Strategies of Bacteroides [PDF]

Shipin Kexue
Bacteroides is one of the core members of the human gut microbial community. With the remarkable capability to degrade complex polysaccharides and producing abundant metabolites, it holds great potential and research value as a next-generation probiotic.
KUANG Cong, SONG Xin, YANG Yijin, WANG Guangqiang, XIE Fan, AI Lianzhong, XIA Yongjun
doaj   +1 more source

Dissolved storage glycans shaped the community composition of abundant bacterioplankton clades during a North Sea spring phytoplankton bloom

Microbiome, 2023
Background Blooms of marine microalgae play a pivotal role in global carbon cycling. Such blooms entail successive blooms of specialized clades of planktonic bacteria that collectively remineralize gigatons of algal biomass on a global scale.
Chandni Sidhu, Inga V. Kirstein, Cédric L. Meunier, Johannes Rick, Vera Fofonova, Karen H. Wiltshire, Nicola Steinke, Silvia Vidal-Melgosa, Jan-Hendrik Hehemann, Bruno Huettel, Thomas Schweder, Bernhard M. Fuchs, Rudolf I. Amann, Hanno Teeling   +13 more
doaj   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source