Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines. [PDF]
Molecules, 2018 The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, has been dramatically reduced over the last 25 years through the use of glycoconjugate
Berti F, De Ricco R, Rappuoli R.
europepmc +2 more sources
Complementary Role of CD4+ T Cells in Response to Pneumococcal Polysaccharide Vaccines in Humans. [PDF]
Vaccines (Basel), 2019 Bacterial pathogens expressing capsular polysaccharides are common causes of mucosal infections (pneumonia, intestinal), as well as often fatal, invasive infections (meningitis, bloodstream infections) in children and adults worldwide.
Jha V, Janoff EN.
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Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella
Polysaccharides, 2021 Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented ...
Sumudu R. Perera +2 more
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The impact of protein-conjugate polysaccharide vaccines: an endgame for meningitis? [PDF]
Philos Trans R Soc Lond B Biol Sci, 2013 The development and implementation of conjugate polysaccharide vaccines against invasive bacterial diseases, specifically those caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, has been one ...
Maiden MC.
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Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials [PDF]
BMC Family Practice, 2000 The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and ...
R Andrew Moore +2 more
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The Current Status in Terms of Vaccination for Individuals Infected with Human Immunodeficiency Virus [PDF]
VirusesHuman immunodeficiency virus (HIV)-infected individuals have an increased risk of various infections due to their impaired host immune system, resulting in higher morbidity and mortality rates.
Nan Xu +3 more
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The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines [PDF]
Infection and Immunity, 1997 Michael H. Shearer +7 more
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Evaluation of the Induction of Immune Memory following Infant Immunisation with Serogroup C Neisseria meningitidis Conjugate Vaccines - Exploratory Analyses within a Randomised Controlled Trial [PDF]
, 2014 Aim: We measured meningococcal serogroup C (MenC)-specific memory B-cell responses in infants by Enzyme-Linked Immunospot (ELISpot) following different MenC conjugate vaccine schedules to investigate the impact of priming on immune memory.
Birks, Jacqueline +7 more
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ACS Infectious Diseases, 2023 The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx. The complex glycans in the glycocalyx are involved in various biological events, such as bacterial pathogenesis, protection of bacteria from environmental ...
Rajendra S Rohokale, Zhongwu Guo
semanticscholar +1 more source
Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Bioengineering, 2022 Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain.
Victor Morais, Norma Suarez
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