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CONJUGATED POLYSACCHARIDE VACCINES
Infectious Disease Clinics of North America, 1999The joining of polysaccharide antigens to various proteins can result in increased immunogenicity of vaccines composed of such antigens. This article discusses conjugated polysaccharide vaccines for Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitis.
H, Ahmad, E K, Chapnick
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Polysaccharide Conjugate Typhoid Vaccine
New England Journal of Medicine, 2001There is a growing appreciation of the huge health threat posed by increasingly resistant infectious diseases, especially in tropical areas of the developing world.
R L, Guerrant, M, Kosek
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Polysaccharides as vaccine adjuvants
Vaccine, 2018Adjuvant is a substance added to vaccine to improve the immunogenicity of antigens, and it can induce stronger immune responses and reduce the dosage and production cost of vaccine in populations responding poorly to vaccination. Adjuvants in development or in use mainly include aluminum salts, oil emulsions, saponins, immune-stimulating complexes ...
Beini, Sun +5 more
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Vaccines Against Polysaccharide Antigens
Current Drug Target -Infectious Disorders, 2001Encapsulated bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae serogroup B (Hib) are a major cause of disease worldwide. Vaccine development against these organisms has targeted their capsular polysaccharides (CPS), as anti-capsular antibodies often protect against disease.
G B, Lesinski, M A, Westerink
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Pneumococcal Polysaccharide Vaccines
Clinical Infectious Diseases, 1989Pneumococcal infections are major causes of morbidity and mortality in children throughout the world. For this reason and because of the increasingly frequent isolation of multiply resistant pneumococci of the serotypes most often causing infection in childhood, prophylactic immunization offers the best prospect of reducing the incidence of such ...
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Capsular polysaccharide vaccines today
Infection, 1984Polysaccharide (PS) vaccines are a relatively new class of antibacterial vaccines that have special advantages but also special problems related to their character. Several of them have proven very effective in preventing bacteremic infections caused by encapsulated bacteria such as meningococci, pneumococci and Haemophilus influenzae type b ...
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Capsular Polysaccharides as Human Vaccines
1983Publisher Summary This chapter discusses the use of capsular polysaccharides as human vaccines. Vaccination has proved to be one of the most useful scientific developments in the control and eradication of human disease. Early vaccines were based on whole-organism preparations or on protein toxins isolated from different bacteria.
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Capsular Polysaccharides as Vaccine Candidates
1990The discovery of a “specific soluble substance” secreted by pneumococci during growth (Dochez and Avery 1917) and the identification of this substance as a carbohydrate (Heidelberger and Avery 1923) were new and important developments in vaccine technology.
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