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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, 2018Polysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in protein formulations.
Michael T. Jones +14 more
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Safety of Polysorbate 80 in the Oncology Setting [PDF]
Advances in Therapy, 2018 Polysorbate 80 is a synthetic nonionic surfactant used as an excipient in drug formulation. Various products formulated with polysorbate 80 are used in the oncology setting for chemotherapy, supportive care, or prevention, including docetaxel, epoetin/darbepoetin, and fosaprepitant.
Lee Schwartzberg
exaly +3 more sources
The determination of polysorbate 60 in foods
Journal of the American Oil Chemists' Society, 1971AbstractAnalytical methods have been developed for the determination of polysorbate 60 (Tween 60, Atlas Chemical Industries, Inc.) in several food products including baked bread and cake, cake mix, yeastraised doughnuts, shortening, foam‐mat dried tomato paste and citrus fruit juices, dressings for salad, and potato flakes.
C F, Smullin +2 more
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Lonophoric Properties of Polysorbate 80
Journal of Pharmaceutical Sciences, 1986Polysorbate 80, a surfactant often assumed to be inert, was found to bind a number of biochemically important ions (K+, Na+, NH4+, Ca2+) and transport them through a model membrane (CH2Cl2). The rates and fluxes of potassium ions were found to depend on the initial concentration of potassium ion, the polysorbate 80 concentration, the temperature, and ...
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Polysorbate Degradation and Quality
2018Among many other applications, polysorbates (PSs) are used as the most common surfactants in biopharmaceutical products in particular to protect proteins against interfacial stress. Structural heterogeneity, presence of degradants and other impurities, and tendency for degradation are interrelated features found in commercial PSs with a direct impact ...
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