Quantitative Assessment of Total Aerobic Viable Counts in Apitoxin-, Royal-Jelly-, Propolis-, Honey-, and Bee-Pollen-Based Products Through an Automated Growth-Based System. [PDF]
Prada-Ramírez HA +14 more
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Comparative Analytics and Pharmacodynamics of the Complex Protein-Free Botulinum Toxin Type A Formulations DaxibotulinumtoxinA, IncobotulinumtoxinA and RelabotulinumtoxinA. [PDF]
Honndorf S +7 more
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Development of an Analytical Procedure for the Quantification of Artemisinin in Encapsulated Formulations. [PDF]
Šijanec A +3 more
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Adsorption of Mixed Micelles of Polysorbate 80 and Oleic Acid to the Air-Water Interface. [PDF]
Ayati NS +7 more
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Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations. [PDF]
Ghosh I +4 more
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The Characterization of Polysorbate
Current Protocols, 2022AbstractPolysorbates (PSs), including PS20 and PS80, are non‐ionic surfactants widely used in the pharmaceutical industry to enhance drug solubility and stability. Despite their wide application, PSs are prone to degradation by either hydrolysis or oxidation in drug formulations during storage; therefore, a PS characterization method assessing protein ...
Sisi, Zhang, Hui, Xiao, Ning, Li
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Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature.
M, Donbrow, E, Azaz, A, Pillersdorf
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The CMC of a series of polysorbates was determined using a surface tension method. The CMC values obtained did not vary to any appreciable extent from those determined by other techniques, indicating that the procedure adopted was reliable, simple, and fast. The application of the usual correction factors was not necessary in the calculation of the CMC
L S, Wan, P F, Lee
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Using the analytical constants for sorbitan monolaurate, monopalmitate, monostearate, and monooleate given in the National Formulary (NF), calculations were carried out that indicated that these emulsifiers are esters of sorbitol mono- and dianhydrides. Contrary to the NF description, no significant amount of sorbitol ester was calculated to be present,
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