Results 191 to 200 of about 257,706 (241)
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Journal of Pharmaceutical Sciences, 1978
Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature.
M, Donbrow, E, Azaz, A, Pillersdorf
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Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature.
M, Donbrow, E, Azaz, A, Pillersdorf
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Journal of Pharmaceutical Sciences, 1974
The CMC of a series of polysorbates was determined using a surface tension method. The CMC values obtained did not vary to any appreciable extent from those determined by other techniques, indicating that the procedure adopted was reliable, simple, and fast. The application of the usual correction factors was not necessary in the calculation of the CMC
L S, Wan, P F, Lee
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The CMC of a series of polysorbates was determined using a surface tension method. The CMC values obtained did not vary to any appreciable extent from those determined by other techniques, indicating that the procedure adopted was reliable, simple, and fast. The application of the usual correction factors was not necessary in the calculation of the CMC
L S, Wan, P F, Lee
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Drug Development and Industrial Pharmacy, 1998
Using the analytical constants for sorbitan monolaurate, monopalmitate, monostearate, and monooleate given in the National Formulary (NF), calculations were carried out that indicated that these emulsifiers are esters of sorbitol mono- and dianhydrides. Contrary to the NF description, no significant amount of sorbitol ester was calculated to be present,
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Using the analytical constants for sorbitan monolaurate, monopalmitate, monostearate, and monooleate given in the National Formulary (NF), calculations were carried out that indicated that these emulsifiers are esters of sorbitol mono- and dianhydrides. Contrary to the NF description, no significant amount of sorbitol ester was calculated to be present,
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Stability of Biologics and the Quest for Polysorbate Alternatives
Trends in Biotechnology, 2021Most biopharmaceutical formulations use polysorbates: surfactants that are highly efficient but difficult to manage in terms of compositional variability, quality, and stability. Alternatives, such as poloxamers, albumin, and cyclodextrin, are becoming popular and are being explored for their potential to protect biopharmaceuticals against physical and
Sachin Dubey, Roberto Giovannini
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, 2018Polysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in protein formulations.
Michael T. Jones +14 more
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The determination of polysorbate 60 in foods
Journal of the American Oil Chemists' Society, 1971AbstractAnalytical methods have been developed for the determination of polysorbate 60 (Tween 60, Atlas Chemical Industries, Inc.) in several food products including baked bread and cake, cake mix, yeastraised doughnuts, shortening, foam‐mat dried tomato paste and citrus fruit juices, dressings for salad, and potato flakes.
C F, Smullin +2 more
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Challenges in polysorbate characterization by mass spectrometry
Rapid Communications in Mass Spectrometry, 2020Polysorbates are used in a variety of applications over a wide range of markets. Simple in concept, these products are complex in actual composition. Mass spectrometry and related techniques have been effectively used to characterize these products, from the major components to the minor residual production byproducts and degradation species.
Kevin W. Penfield, Stephen Rumbelow
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Pharmaceutical Research, 2002
Polysorbate 20 is a commonly used excipient in biopharmaceutical formulations, some of which may have an enzymatic activity. The action(s) of polysorbate 20 in biopharmaceutical formulations as a stabilizer require this surfactant to maintain its intact structure.
Mehrnaz, Khossravi +3 more
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Polysorbate 20 is a commonly used excipient in biopharmaceutical formulations, some of which may have an enzymatic activity. The action(s) of polysorbate 20 in biopharmaceutical formulations as a stabilizer require this surfactant to maintain its intact structure.
Mehrnaz, Khossravi +3 more
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Lonophoric Properties of Polysorbate 80
Journal of Pharmaceutical Sciences, 1986Polysorbate 80, a surfactant often assumed to be inert, was found to bind a number of biochemically important ions (K+, Na+, NH4+, Ca2+) and transport them through a model membrane (CH2Cl2). The rates and fluxes of potassium ions were found to depend on the initial concentration of potassium ion, the polysorbate 80 concentration, the temperature, and ...
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Polysorbate 80 and E-Ferol Toxicity
Pediatrics, 1986The relatively recent introduction and use of an intravenous form of a vitamin E preparation (E-Ferol) has been associated with the development of an unusual syndrome and fatalities among low birth weight (<1,500 g), premature infants in neonatal intensive care units.
S L, Alade, R E, Brown, A, Paquet
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