Results 61 to 70 of about 439,320 (307)

Experimental and clinical study of the efficacy of medicines containing omega-3 and 6 polyunsaturated fatty acids, in the treatment of inflammatory skin diseases [PDF]

, 2018
Over the recent years, the attention of scientists regarding the search for alternative means of treatment, including local therapy, of inflammatory skin diseases, has been focused in recent years on medicines containing omega-3 and 6 polyunsaturated ...
Grebennikova, S. V., Maklyakov, Y. S.
core   +3 more sources

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Relationship between Polyunsaturated Fatty Acid Metabolism and Atherosclerosis

Reviews in Cardiovascular Medicine
Multiple factors cause atherosclerosis, meaning its pathogenesis is complex, and has not been fully elucidated. Polyunsaturated fatty acids are a member of the fatty acid family, which are critical nutrients for mammalian growth and development.
Qiulei Liu, Zhaoxuan Liu, Ding Wu, Sheng Wang   +3 more
doaj   +1 more source

Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood–brain barrier endothelial cells in vitro

Journal of Lipid Research, 1998
To determine the respective roles of endothelial cells from brain capillaries and astrocytes in the conversion of circulating 18:2n–6 and 18:3n–3 into 20:4n–6 and 22:6n–3, respectively, a coculture of the two cell types mimicking the in vivo blood–brain ...
N. Bernoud, L. Fenart, C. Bénistant, J.F. Pageaux, M.P. Dehouck, P. Molière, M. Lagarde, R. Cecchelli, J. Lecerf   +8 more
doaj   +1 more source

The compositional and metabolic responses of gilthead seabream (Sparus aurata) to a gradient of dietary fish oil and associated n-3 long-chain PUFA content [PDF]

, 2017
The authors express their gratitude to the technical team at the BioMar Feed Trial Unit, Hirtshals, in particular, Svend Jørgen Steenfeldt for expert care of the experimental subjects, for training and supervision provided by laboratory staff at ...
Betancor, Mónica B, Houston, Sam J S, Karalazos, Vasileios, Martin, Samuel A M, Monroig, Oscar, Tinsley , John, Tocher, Douglas R   +6 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men

Asian Journal of Andrology, 2017
Emerging evidence suggests that dietary fats may influence testicular function. However, most of the published literature on this field has used semen quality parameters as the only proxy for testicular function. We examined the association of fat intake
Lidia Mínguez-Alarcón, Jorge E Chavarro, Jaime Mendiola, Manuela Roca, Cigdem Tanrikut, Jesús Vioque, Niels Jørgensen, Alberto M Torres-Cantero   +7 more
doaj   +1 more source

Overweight and erythrocyte polyunsaturated fatty acid changes in menopause

The EuroBiotech Journal, 2020
Lipid disorders have been implicated in overweight and menopause. However, evidence on lipidomic analysis of fatty acids in erythrocytes of menopausal women is scarce.
D’Alberti Giulia, Ferreri Carla, Larocca Anna Vita, Torquato Pierangelo, Boccuto Antonio, Gizzi Chiara, Albi Elisabetta   +6 more
doaj   +1 more source

Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy [PDF]

, 2016
Context: Docosahexaenoic acid (DHA) is an important fatty acid required for neurological development but its importance during early fetal neurological organogenesis is unknown.
Brown, E. Ann, Freeman, Dilys J., Jordan, Fiona, Lyall, Helen, Meyer, Barbara J., Murray, Heather, Nelson, Scott M., Nibbs, Robert J. B., Onyiaodike, Christopher C., Sattar, Naveed   +9 more
core   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source