Results 211 to 220 of about 41,053 (237)

The Dynamic Nature of the POMC Neuron Landscape, and the Impact of POMC Peptides and Body Composition States in Motivated Feeding

, 2019
Graham L. Jones
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Central Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Neuron-Specific Proopiomelanocortin-Deficient Mice

, 2006
Low, Malcolm J., Otero-Corchon, Veronica, Smart, James L., Tolle, Virgine   +3 more
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Author response: POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia León, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Víctor M Navarro   +11 more
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Thalamic opioids from POMC satiety neurons switch on sugar appetite

Science
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the neurobiological mechanisms that underlie the selective appetite for sugar in states of satiety remain unclear.
Minère, Marielle, Wilhelms, Hannah, Kuzmanovic, Bojana, Lundh, Sofia, Fusca, Debora, Claßen, Alina, Shtiglitz, Stav, Prilutski, Yael, Talpir, Itay, Tian, Lin, Kieffer, Brigitte, Davis, Jon, Kloppenburg, Peter, Tittgemeyer, Marc, Livneh, Yoav, Fenselau, Henning   +15 more
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Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype

European Journal of Neuroscience, 2006
AbstractNeuronal networks originating in the hypothalamic arcuate nucleus play fundamental roles in the control of energy balance. Neuropeptide Y (NPY)‐producing neurons in the arcuate nucleus stimulate food intake, whereas arcuate nucleus neurons that release the proopiomelanocortin (POMC)‐derived peptide α‐melanocyte‐stimulating hormone (α‐MSH ...
Björn, Meister, Burçak, Gömüç, Elisabet, Suarez, Yuko, Ishii, Katrin, Dürr, Linda, Gillberg   +5 more
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PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake

American Journal of Physiology-Endocrinology and Metabolism, 2010
Both insulin and leptin signaling converge on phosphatidylinositol 3-OH kinase [PI( 3 )K]/3-phosphoinositide-dependent protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI( 3 )K-dependent manner.
Kristy, Iskandar, Yongheng, Cao, Yoshitake, Hayashi, Masanori, Nakata, Eisuke, Takano, Toshihiko, Yada, Changliang, Zhang, Wataru, Ogawa, Miyo, Oki, Streamson, Chua, Hiroshi, Itoh, Tetsuo, Noda, Masato, Kasuga, Jun, Nakae   +13 more
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Mitochondrial regulation of obesity by POMC neurons

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Pro-opiomelanocortin (POMC) neurons, nestled in the hypothalamus, play a pivotal role in the intricate coordination of energy homeostasis and metabolic pathways. These neurons' mitochondria, often hailed as the cell's powerhouses, are crucial for maintaining cellular energy equilibrium and metabolic functionality.
Xing-Dan, Luo, Si, Tang, Xiang-Yun, Luo, Luosang, Quzhen, Ruo-Han, Xia, Xian-Wang, Wang   +5 more
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Estrogen Promotes Parvalbumin Expression in Arcuate Nucleus POMC Neurons

Reproductive Sciences, 2010
We have found that estrogen promotes suppression of feeding and a lean body mass while activating the arcuate nucleus proopiomelanocortin (POMC)-expressing neurons. These neurons, when activated, suppress appetite and increase energy expenditure. Because the increased activation of POMC neurons by estradiol was associated with increased glutamate ...
Peter, Sotonyi, Qian, Gao, Ingo, Bechmann, Tamas L, Horvath   +3 more
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POMC neurons modulate infant vocalizations through opioid signaling

2022
AbstractInfants cry when separated from their mothers. Here, we show that POMC neurons in the arcuate nucleus of the hypothalamus—via ß-endorphin production and signaling—modulate the crying behavior of mouse pups. The effect of POMC neurons on vocal behavior depends on the expression of µ-opioid receptors, the main receptor for ß-endorphin. Thus, POMC
Gabriela M. Bosque Ortiz, Marcelo O. Dietrich   +1 more
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POMC Neurons: Feeding, Energy Metabolism, and Beyond

2018
The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are three key components of the central melanocortin pathway.
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