Results 191 to 200 of about 39,809 (238)

Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning.

Eur J Pharm Biopharm, 2016
Marano S, Barker SA, Raimi-Abraham BT, Missaghi S, Rajabi-Siahboomi A, Craig DQM.   +5 more
europepmc   +1 more source

Unexpected Effect of Digestion Products of Infant Formula in Enhancing the Solubilisation of Tolfenamic Acid During Digestion. [PDF]

Pharmaceutics
Eason T, Salim M, Zann V, Boyd BJ.
europepmc   +1 more source

The Role and Potential of Nanotechnology in Improving Solubility and Enhancing Bioavailability. [PDF]

Pharmaceutics
Hosszú Z, Pártos P, Mahdavi M, Ujhelyi Z, Fehér P, Haimhoffer Á, Bácskay I, Kósa D, Pető Á.   +8 more
europepmc   +1 more source

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Drug delivery strategies for poorly water-soluble drugs: the industrial perspective

Expert Opinion on Drug Delivery, 2011
For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Peter Van Hoogevest
exaly   +3 more sources

Nanoparticles: A personal experience for formulating poorly water soluble drugs

Journal of Controlled Release, 2010
This short paper is a personal account of the development of techniques to enhance the bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer size range. This is a nanotechnological approach which has come of age and has had a practical impact on drug delivery. The drug is in effect the nanosystem.
exaly   +3 more sources

Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs

Molecular Pharmaceutics, 2022
While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of the barriers of conventional vehicles for the delivery of hydrophobic ...
Ridhdhi Dave, Gurpreet Randhawa, Daeun Kim, Madeline Simpson, Todd Hoare   +4 more
openaire   +2 more sources

Nanoprecipitation for Poorly Water-Soluble Drugs

Current Drug Metabolism, 2018
More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen, Van-Thanh, Tran, Wei, Duan, Phuong H L, Tran, Thao T D, Tran   +4 more
openaire   +2 more sources

Nanonization strategies for poorly water-soluble drugs

Drug Discovery Today, 2011
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen, Chalermchai, Khemtong, Xiangliang, Yang, Xueling, Chang, Jinming, Gao   +4 more
openaire   +2 more sources

Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Journal of Pharmaceutical Sciences, 2010
The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim, Sungwon, Kim, Michelle, Papp, Kinam, Park, Rodolfo, Pinal   +4 more
openaire   +2 more sources

Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds

Toxicologic Pathology, 2008
More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge, Gary G, Liversidge   +1 more
openaire   +2 more sources