Results 251 to 260 of about 121,997 (290)
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Improving “gut feelings” for poorly water-soluble drugs
Science Translational Medicine, 2018A nanocarrier system self-assembled in the intestine significantly improves oral availability of poorly water-soluble drugs.
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Microcrystals for dissolution rate enhancement of poorly water-soluble drugs
International Journal of Pharmaceutics, 2003Slight dissolution rates related to poor water-solubility are one of the well-known difficulties to be covered during the development of new drug substances. The poorly water-soluble drug ECU-01, a low molecular enzyme-inhibitor with anti-inflammatory properties for oral administration, shows a poor dissolution rate.
Norbert, Rasenack +2 more
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Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs
International Journal of Pharmaceutics, 2014Enhanced recovery/dissolution of two wet media-milled, poorly water-soluble drugs, Griseofulvin (GF) and Azodicarbonamide (AZD), incorporated into nanocomposite microparticles (NCMPs) via fluidized bed drying (FBD) and spray-drying (SD) was investigated.
Anagha, Bhakay +3 more
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Optimizing the Formulation of Poorly Water-Soluble Drugs
2011With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development.
Kevin P. O’Donnell, Robert O. Williams
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Nanoparticles: A personal experience for formulating poorly water soluble drugs
Journal of Controlled Release, 2010This short paper is a personal account of the development of techniques to enhance the bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer size range. This is a nanotechnological approach which has come of age and has had a practical impact on drug delivery. The drug is in effect the nanosystem.
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Supercritical Fluid Particle Design for Poorly Water-soluble Drugs (Review)
Current Pharmaceutical Design, 2014Supercritical fluid particle design (SCF PD) offers a number of routes to improve solubility and dissolution rate for enhancing the bioavailability of poorly water-soluble drugs, which can be adopted through an in-depth knowledge of SCF PD processes and the molecular properties of active pharmaceutical ingredients (API) and drug delivery system (DDS ...
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Injectable Formulations of Poorly Water-Soluble Drugs
2022Hannah L. O’Mary, Zhengrong Cui
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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