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Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drugs
International Journal of Pharmaceutics, 2013 Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products.
Huiling Mu, René Holm, Anette Müllertz
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Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration
Journal of Biomedical Nanotechnology, 2011Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir +6 more
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Drug Delivery Strategies for Poorly Water-Soluble Drugs: The Industrial Perspective
Expert Opinion on Drug Delivery, 2011For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Xiangli Liu, Peter van Hoogevest
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
Toxicologic Pathology, 2008More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge +1 more
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Pharmaceutical Methods for Enhancing the Dissolution of Poorly Water-Soluble Drugs
ASSAY and Drug Development Technologies, 2023Low water solubility is the main hindrance in the growth of pharmaceutical industry. Approximately 90% of newer molecules under investigation for drugs and 40% of novel drugs have been reported to have low water solubility. The key and thought-provoking task for the formulation scientists is the development of novel techniques to overcome the ...
Tahir Mahmood +4 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2011A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
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Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions
Recent Patents on Drug Delivery & Formulation, 2013Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on ...
Thao T-D, Tran +4 more
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Nanoparticles: A Personal Experience for Formulating Poorly Water Soluble Drugs
Journal of Controlled Release, 2010This short paper is a personal account of the development of techniques to enhance the bioavailability of a series of poorly soluble drugs by particle size reduction to the nanometer size range. This is a nanotechnological approach which has come of age and has had a practical impact on drug delivery. The drug is in effect the nanosystem.
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Optimizing the Formulation of Poorly Water-Soluble Drugs
2011With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development.
Kevin P. O’Donnell, Robert O. Williams
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