Results 221 to 230 of about 7,280,281 (268)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning.

Eur J Pharm Biopharm, 2016
Marano S, Barker SA, Raimi-Abraham BT, Missaghi S, Rajabi-Siahboomi A, Craig DQM.   +5 more
europepmc   +1 more source

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Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs

Molecular Pharmaceutics, 2022
While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of the barriers of conventional vehicles for the delivery of hydrophobic ...
Ridhdhi Dave, Gurpreet Randhawa, Daeun Kim, Madeline Simpson, Todd Hoare   +4 more
openaire   +2 more sources

Oral Drug Delivery Strategies for Development of Poorly Water Soluble Drugs in Paediatric Patient Population [PDF]

Advanced Drug Delivery Reviews, 2022
Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies are available to
Fiona OʼBrien, Sandra Klein, Carsten Timpe   +2 more
exaly   +2 more sources

Nanoprecipitation for Poorly Water-Soluble Drugs

Current Drug Metabolism, 2018
More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen, Van-Thanh, Tran, Wei, Duan, Phuong H L, Tran, Thao T D, Tran   +4 more
openaire   +2 more sources

Nanonization strategies for poorly water-soluble drugs

Drug Discovery Today, 2011
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen, Chalermchai, Khemtong, Xiangliang, Yang, Xueling, Chang, Jinming, Gao   +4 more
openaire   +2 more sources

Hydrotropic Solubilization of Poorly Water-Soluble Drugs

Journal of Pharmaceutical Sciences, 2010
The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim, Sungwon, Kim, Michelle, Papp, Kinam, Park, Rodolfo, Pinal   +4 more
openaire   +2 more sources

Successful Oral Delivery of Poorly Water-Soluble Drugs Both Depends on the Intraluminal Behavior of Drugs and of Appropriate Advanced Drug Delivery Systems [PDF]

European Journal of Pharmaceutical Sciences, 2019
Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a ...
Ben J. Boyd, Neha Shrestha, Annette Bauer-Brandl   +2 more
exaly   +2 more sources