Results 71 to 80 of about 699,916 (288)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Daily contact with a patient and poor housing affordability as determinants of pulmonary tuberculosis in urban Pakistan

International Journal of Mycobacteriology, 2013
Objective: This study aimed to evaluate the factors associated with pulmonary tuberculosis (TB) among individuals aged 15 years or more in urban Karachi, Pakistan.
Batool A Haider, Saeed Akhtar, Juanita Hatcher   +2 more
doaj   +1 more source

Surveillance for melanoma and other skin cancers at the regional level

Фундаментальная и клиническая медицина, 2020
Aim. To justify the proposals for improving the surveillance for melanoma and non-melanoma skin cancers at the regional level.Materials and Methods. We conducted a cross-sectional study investigating the prevalence of known risk factors for melanoma and ...
A. I. Blokh, V. L. Stasenko
doaj   +1 more source

Risk‐Attributable Burden of Ischemic Heart Disease in 137 Low‐ and Middle‐Income Countries From 2000 to 2019

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ischemic heart disease (IHD) imposes the greatest disease burden globally, especially in low‐ and middle‐income countries (LMICs). We aim to examine the population‐attributable fraction and risk‐attributable death and disability‐adjusted life ...
Chenran Wang, Yanghua Sun, Di Jiang, Chunping Wang, Shiwei Liu   +4 more
doaj   +1 more source

The global burden attributable to low bone mineral density [PDF]

, 2017
Introduction: The Global Burden of Disease Study 2010 estimated the worldwide health burden of 291 diseases and injuries and 67 risk factors by calculating disability-adjusted life years (DALYs).
Carnahan, E., Chen, J. S., Hoy, D., Kamalaraj, N., Kok, C., Li, Y., Lim, S. S., Macara, M., March, Lyn, Nolla Solé, Joan Miquel, Norman, R., Santos-Hernández, C., Smith, E., Sànchez Riera, Lídia, Veerman, L., Vos, Theo, Wilson, N.   +16 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Relative and Attributable Risk for Cervical Cancer: A Comparative Study in the United States and Italy [PDF]

, 2017
Parazzini F {Istituto di Ricerche Farmacologiche ‘Mario Negri' via Eritrea 62,20157 Milan, Italy), Hildesheim A, Ferraroni M, La Vecchia C and Brinton LA.
BRINTON, LOUISE A., FERRARONI, MONICA, HILDESHEIM, ALLAN, PARAZZINI, FABIO, VECCHIA, CARLO LA   +4 more
core  

Clinical malaria case definition and malaria attributable fraction in the highlands of western Kenya. [PDF]

, 2014
BackgroundIn African highland areas where endemicity of malaria varies greatly according to altitude and topography, parasitaemia accompanied by fever may not be sufficient to define an episode of clinical malaria in endemic areas.
Afrane, Yaw A, Githeko, Andrew K, Yan, Guiyun, Zhou, Guofa   +3 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source