The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data. [PDF]
PLoS Genetics, 2010 We consider the feasibility of reusing existing control data obtained in genetic association studies in order to reduce costs for new studies. We discuss controlling for the population differences between cases and controls that are implicit in studies ...
Gary K Chen +12 more
doaj +1 more source
Relationship between adiposity and admixture in African-American and Hispanic-American women. [PDF]
, 2012 ObjectiveThe objective of this study was to investigate whether differences in admixture in African-American (AFA) and Hispanic-American (HA) adult women are associated with adiposity and adipose distribution.DesignThe proportion of European, sub-Saharan
Allison, M +10 more
core
Genetics, 2019 Characterizing genetic variation in humans is an important task in statistical genetics, enabling disease-gene mapping in genome-wide association studies (GWAS) and informing studies of human evolutionary history. A common approach to quantifying genetic
Irineo Cabreros, John D. Storey
semanticscholar +1 more source
Inferring the ancestry of parents and grandparents from genetic data.
PLoS Computational Biology, 2020 Inference of admixture proportions is a classical statistical problem in population genetics. Standard methods implicitly assume that both parents of an individual have the same admixture fraction. However, this is rarely the case in real data.
Jingwen Pei +3 more
doaj +1 more source
The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa [PDF]
, 2016 Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I ...
Alexander, Alice A +10 more
core +1 more source
The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
Animal, 2019 The Mangalitza pig breed has suffered strong population reductions due to competition with more productive cosmopolitan breeds. In the current work, we aimed to investigate the effects of this sustained demographic recession on the genomic diversity of ...
V.A. Bâlteanu +6 more
doaj +1 more source
Admixture-enabled selection for rapid adaptive evolution in the Americas
Genome Biology, 2020 Background Admixture occurs when previously isolated populations come together and exchange genetic material. We hypothesize that admixture can enable rapid adaptive evolution in human populations by introducing novel genetic variants (haplotypes) at ...
Emily T. Norris +6 more
doaj +1 more source
Putting RFMix and ADMIXTURE to the test in a complex admixed population
BMC Genetics, 2019 Global and local ancestry inference in admixed human populations can be performed using computational tools implementing distinct algorithms. The development and resulting accuracy of these tools has been tested largely on populations with relatively ...
C. Uren, E. Hoal, M. Möller
semanticscholar +1 more source
Legofit: estimating population history from genetic data
BMC Bioinformatics, 2019 Background Our current understanding of archaic admixture in humans relies on statistical methods with large biases, whose magnitudes depend on the sizes and separation times of ancestral populations.
Alan R. Rogers
doaj +1 more source
Evolutionary associations between sand seatrout (Cynoscion arenarius) and silver seatrout (C. nothus) inferred from morphological characters, mitochondrial DNA, and microsatellite markers [PDF]
, 2009 The evolutionary associations between closely related fish species, both contemporary and historical, are frequently assessed by using molecular markers, such as microsatellites.
Anderson, Joel D. +3 more
core