Results 71 to 80 of about 704,078 (308)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Why Does Population Aging Matter So Much for Asia? Population Aging, Economic Security and Economic Growth in Asia [PDF]
Asia as a whole is experiencing a rapid demographic transition toward older population structures. Within this broader region-wide trend, there is considerable heterogeneity, with different countries at different stages of the demographic transition.
Andrew MASON +2 more
core
Economic Security in an Aging Canadian Population [PDF]
This paper has been written to bring up to date materials in a monograph that was a part of the Butterworths series of monographs in social gerontology, in particular, the 1991 monograph entitled: Economic Security in an Aging Population (Brown, 1991 ...
Robert L. Brown
core +2 more sources
BMC Primary CareBackground The management of inappropriate medication use in older patients suffering from multimorbidity and polymedication is a major healthcare challenge.
Carmela Bou Malham +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Brain, Behavior, & Immunity - HealthSocio-environmental and health-related variables were examined in relation to longitudinal change in select neuroimaging markers through metabolomics. Data from 2255 dementia-free UK Biobank participants were utilized.
May A. Beydoun +10 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Dependence and Population Ageing [PDF]
SSRN Electronic Journal, 1991 Population ageing has often been summarised through rising old-age dependence ratios. Age is therefore perceived as a source of dependence, which supposedly causes economic problems. While these perceptions seem intuitive, they are open to query and may be misleading.
openaire +3 more sources
Population Aging, Productivity, and Growth in Living Standards [PDF]
Population aging creates both a problem (higher taxes on a small group of workers to finance higher public pension and health care costs) and automatic adjustments that help to address that problem. The prospect of longer retirement involves an increased
William Scarth
core
Expanding the agenda for research on the physically active aging body
, 2009 In this article, the authors consider the different approaches that can be used to examine the relationship between physical activity and aging. They propose that much is to be gained in our awareness of this dynamic relationship by drawing on multiple ...
Phoenix, Cassandra +5 more
core +1 more source