Results 101 to 110 of about 615,397 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation

, 2009
In this study, a dynamic model is presented for the granulation process, employing a three-dimensional Population balance framework. As a first attempt to account for the multi-scale character of the process, the nucleation and aggregation kernels used ...
Sanders, C.F., Glaser, T., Immanuel, C.D., Cameron, I.T., Doyle, F.J., Wang, F.Y., Ramachandran, R., Litster, J.D., Poon, J.M., Stepanek, F.   +9 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development of a multi-compartment population balance model for high-shear wet granulation with Discrete Element Method [PDF]

, 2016
This paper presents a multi-compartment population balance model for wet granulation coupled with DEM (Discrete Element Method) simulations. Methodologies are developed to extract relevant data from the DEM simulations to inform the population balance ...
McGuire, Andrew D., Dosta, Maksym, Lee, Kok Foong, Heinrich, Stefan, Wagner, Wolfgang, Mosbach, Sebastian, Kraft, Markus   +6 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Potential Material Flow of WEEE in a Data-Constrained Environment—The Case of Jordan

Recycling
The rising concerns about electric and electronic equipment waste (WEEE) come from the rapid increase in demand for appliances and the decreasing lifetimes of equipment.
Laila A. Al-Khatib, Feras Y. Fraige
doaj   +1 more source

Outlier analysis for a silicon nanoparticle population balance model

, 2018
We assess the impact of individual experimental observations on a multivariate population balance model for the formation of silicon nanoparticles from the thermal decomposition of silane by means of basic regression influence diagnostics.

core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis of Oil Droplet Coalescence and Breakage Characteristics in Double Branch T Junction Pipe

Shiyou jixie, 2020
Existing studies do not further analyze the coalescence and breakage of oil droplets in T junction pipe, and the study on coalescence and breakage characteristics of oil droplets in double-branch T junction pipe using PBM model has not been reported.
Li Feng, Gao Jinming, Xing Lei, Liu Caiyu, Xiong Feng   +4 more
doaj