Results 101 to 110 of about 2,848,057 (332)

Population dynamics and prey selection of native and introduced predators during a rodent outbreak in arid Australia [PDF]

, 2008
Chris R. Pavey, Stephen R. Eldridge, M. Heywood   +2 more
openalex   +1 more source

Mate limitation, recurrent epidemic outbreaks, and the coexistence of sexual and asexual plant parasites [PDF]

, 2014
To date, relatively few studies have focused on the effects of sex on population dynamics. Previous models found that sexual reproduction may either dampen population fluctuations or accentuate population fluctuations, depending on mating system notably.
Hamelin, Frédéric, Lemesle, Valérie, Mailleret, Ludovic, Ravigné, Virginie   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Annealing schedule from population dynamics

, 1999
We introduce a dynamical annealing schedule for population-based optimization algorithms with mutation. On the basis of a statistical mechanics formulation of the population dynamics, the mutation rate adapts to a value maximizing expected rewards at ...
A. Prügel-Bennett, A. Prügel-Bennett, D. B. Fogel, E. Aarts, F. Starrost, I. Rechenberg, J. H. Holland, J. L. Shapiro, L. M. Rattray, M. Mitchell, P. Stadler, P. Sutton, S. Bornholdt, S. Kauffman, S. Kauffman, Stefan Bornholdt   +15 more
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Factors associated with consistent condom use: a cross-sectional survey of two Nigerian universities

BMC Public Health, 2019
Background Consistent condom use is central to the prevention of transmission of human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs), especially among young adults.
Anthony Idowu Ajayi, Kafayat Olanike Ismail, Wilson Akpan   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Short, stringent lockdowns halted SARS-CoV-2 transmissions in Danish municipalities

Scientific Reports
In late 2020, the focus of the global effort against the COVID-19 pandemic centered around the development of a vaccine, when reports of a mutated SARS-CoV-2 virus variant in a population of 17 million farmed mink came from Denmark, threatening to ...
Florian Ege
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Are contributory causes of death in part 2 of the death certificate mediators of chains of morbid events leading to death?

Population Health Metrics
Background In the United States, over half of all deaths are attributed to five leading underlying causes of death (at the ICD-3 digit level). However, these underlying causes represent only 25% of the total medical information documented on death ...
Elizabet Ukolova
doaj   +1 more source