Results 71 to 80 of about 2,869,951 (334)

Matrix methods in health demography: a new approach to the stochastic analysis of healthy longevity and DALYs

Population Health Metrics, 2018
Background Increases in human longevity have made it critical to distinguish healthy longevity from longevity without regard to health. Current methods focus on expectations of healthy longevity, and are often limited to binary health outcomes (e.g ...
Hal Caswell, Virginia Zarulli
doaj   +1 more source

Sociodemographic and lifestyle correlates of exclusive breastfeeding practices among mothers on antiretroviral therapy in the Eastern Cape, South Africa

International Breastfeeding Journal, 2021
Background Exclusive breastfeeding (EBF) is associated with a reduction of postnatal HIV transmission and optimal infant growth. Given that the factors influencing exclusive breastfeeding are multi-factorial and context-specific, we examined the ...
Daniel Ter Goon, Anthony Idowu Ajayi, Oladele Vincent Adeniyi   +2 more
doaj   +1 more source

Complexity and hierarchical game of life

, 2003
Hierarchical structure is an essential part of complexity, important notion relevant for a wide range of applications ranging from biological population dynamics through robotics to social sciences.
Berlekamp E. R., BORIS ZALTZMAN, EUGENE TZVETKOV, Gardner M., ISAAK RUBINSTEIN, IVAN GÖTZ   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Temporal trends in test-seeking behaviour during the COVID-19 pandemic

Mathematics in Medical and Life Sciences
This paper is part of a special issue on Behavioural Epidemiology.Cases identified through mass testing represent only a fraction of infections, depending on the propensity of infected individuals to seek testing.
Oliver Eales, Mingmei Teo, David J. Price, Tianxiao Hao, Gerard E. Ryan, Katharine L. Senior, Sandra Carlson, Craig Dalton, Peter Dawson, Nick Golding, James M. McCaw, Freya M. Shearer   +11 more
doaj   +1 more source

Prevalence and correlates of sexual violence among adolescent girls and young women: findings from a cross-sectional study in a South African university

BMC Women's Health, 2021
Background Epidemiological data on the prevalence and factors associated with sexual violence is critical to understanding the magnitude of the problem and designing effective interventions.
Anthony Idowu Ajayi, Elmon Mudefi, Eyitayo Omolara Owolabi   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cost-effectiveness of inhaled oxytocin for prevention of postpartum haemorrhage: a modelling study applied to two high burden settings

BMC Medicine, 2020
Background Access to oxytocin for prevention of postpartum haemorrhage (PPH) in resource-poor settings is limited by the requirement for a consistent cold chain and for a skilled attendant to administer the injection.
Natalie Carvalho, Mohammad Enamul Hoque, Victoria L. Oliver, Abbey Byrne, Michelle Kermode, Pete Lambert, Michelle P. McIntosh, Alison Morgan   +7 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source