Results 81 to 90 of about 2,847,238 (284)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Odour-mediated sexual attraction in nabids (Heteroptera: Nabidae)

European Journal of Entomology, 2008
In many insects, mate finding is mediated by volatile sex pheromones, but evidence in nabids is still fragmentary. The role of odour-mediated sexual attraction in two nabid species, Nabis pseudoferus and N.
Steffen ROTH, Arne JANSSEN, Maurice W. SABELIS   +2 more
doaj   +1 more source

Annealing schedule from population dynamics

, 1999
We introduce a dynamical annealing schedule for population-based optimization algorithms with mutation. On the basis of a statistical mechanics formulation of the population dynamics, the mutation rate adapts to a value maximizing expected rewards at ...
A. Prügel-Bennett, A. Prügel-Bennett, D. B. Fogel, E. Aarts, F. Starrost, I. Rechenberg, J. H. Holland, J. L. Shapiro, L. M. Rattray, M. Mitchell, P. Stadler, P. Sutton, S. Bornholdt, S. Kauffman, S. Kauffman, Stefan Bornholdt   +15 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Population dynamics of Windermere perch [PDF]

, 1982
This paper looks briefly at some of the more recent analyses and interpretations of the changes that have occurred in the population dynamics of Windermere perch and at the present level of understanding.
Craig, J.F.
core  

Population dynamics in compressible flows

, 2012
Organisms often grow, migrate and compete in liquid environments, as well as on solid surfaces. However, relatively little is known about what happens when competing species are mixed and compressed by fluid turbulence.
A. Kolmogorov, A. Kolmogorov, A. Kurganov, A. Martin, A.P. Martin, A.R. Robinson, A.R. Robinson, C. Torney, D. R. Nelson, D.R. Nelson, F. D’Ovidio, F. Peters, F. Toschi, F. Toschi, G. Boffetta, G. Boffetta, G. Falkovich, I.M. Held, J. Bec, J. Bec, J. Bec, J. ichi Wakita, J. Mannik, J.R. Cressman, K. Korolev, K. Mizobota, K.A. Dahmen, L. Biferale, L. Thomas, M. H. Jensen, M. Kimura, N.M. Shnerb, O. Hallatschek, O. Hallatschek, O. Hallatschek, P. Klein, P. Klein, P. Perlekar, P. Perlekar, R. Benzi, R. Benzi, R. Benzi, R. Fisher, S. Berti, S. Pigolotti, T. Neicu, T. Tel, W. McKiver, W. Saarloos van, W.J. McKiver, W.M. Durham, X. Capet   +51 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain

Cell Reports
Summary: Caloric restriction (CR) is a well-studied intervention that extends lifespan and slows cognitive decline across species, yet the specific cell populations and molecular pathways involved remain elusive. In this study, we profiled >500,000 cells
Zehao Zhang, Alexander Epstein, Chloe Schaefer, Abdulraouf Abdulraouf, Weirong Jiang, Wei Zhou, Junyue Cao   +6 more
doaj   +1 more source

Protective sexual behaviours among young adults in Nigeria: influence of family support and living with both parents

BMC Public Health, 2019
Background Many studies have focused on risky sexual behaviour among adolescents and young adults; however, literature on protective sexual practices among this age cohort is still evolving.
Anthony Idowu Ajayi, Sylvester Reuben Okeke   +1 more
doaj   +1 more source