Results 11 to 20 of about 7,466,882 (388)
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
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Archetypal Analysis for population genetics.
PLoS Computational Biology, 2022 The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse ...
Julia Gimbernat-Mayol +4 more
doaj +1 more source
The population genetics of dN/dS. [PDF]
PLoS Genetics, 2008 Evolutionary pressures on proteins are often quantified by the ratio of substitution rates at non-synonymous and synonymous sites. The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which ...
Sergey Kryazhimskiy, Joshua B Plotkin
doaj +1 more source
Pedigree Analysis: A Team-Based Learning Activity
MedEdPORTAL, 2017 Introduction Regardless of their specialty, physicians, particularly those practicing primary care in rural areas, typically encounter genetic conditions.
Jack Thatcher +3 more
doaj +1 more source
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Nature Communications, 2020 Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue
Qingbo Wang +11 more
doaj +1 more source
The wild tomato species Solanum chilense shows variation in pathogen resistance between geographically distinct populations [PDF]
PeerJ, 2017 Wild tomatoes are a valuable source of disease resistance germplasm for tomato (Solanum lycopersicum) breeders. Many species are known to possess a certain degree of resistance against certain pathogens; however, evolution of resistance traits is yet ...
Remco Stam +2 more
doaj +2 more sources
Arlequin (version 3.0): An integrated software package for population genetics data analysis
Evolutionary bioinformatics online, 2005 Arlequin ver 3.0 is a software package integrating several basic and advanced methods for population genetics data analysis, like the computation of standard genetic diversity indices, the estimation of allele and haplotype frequencies, tests of ...
L. Excoffier +2 more
semanticscholar +1 more source
The nk model and population genetics [PDF]
, 2005 The nk model of fitness interactions is examined. This model has been used by previous authors to investigate the effects of fitness epistasis on substitution dynamics in molecular evolution, and to make broader claims about the importance of epistasis ...
Barton +54 more
core +2 more sources
Ecology and Evolution, 2019 Effective conservation and management of pond‐breeding amphibians depends on the accurate estimation of population structure, demographic parameters, and the influence of landscape features on breeding‐site connectivity.
Kyle A. O'Connell +4 more
doaj +1 more source
A Primer of Population Genetics and Genomics
, 2020 A Primer of Population Genetics and Genomics, 4th edition, has been completely revised and updated to provide a concise but comprehensive introduction to the basic concepts of population genetics and genomics.
D. Hartl
semanticscholar +1 more source