Results 131 to 140 of about 373,456 (271)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
New Stellar Parameters, Metallicities, and Elemental Abundance Ratios for 311 Metal-poor Stars
The Astronomical JournalWe present equivalent widths, improved model atmosphere parameters, and revised abundances for 14 species of 11 elements derived from high-resolution optical spectroscopy of 311 metal-poor stars.
Sanil Mittal, Ian U. Roederer
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
AEOS: Star-by-star Cosmological Simulations of Early Chemical Enrichment and Galaxy Formation
The Astrophysical JournalThe A eos project introduces a series of high-resolution cosmological simulations that model star-by-star chemical enrichment and galaxy formation in the early Universe, achieving 1 pc resolution.
Kaley Brauer +9 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Astrophysical JournalThe main-sequence turnoff (MSTO) stars well preserve the chemical properties where they were born, making them ideal tracers for studying the stellar population. We perform a detailed chemo-dynamical analysis on moderately metal-poor (−2.0
Renjing Xie +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Formation Process of the Young Stellar Population in Messier 16 from a Kinematic Perspective
The Astronomical JournalWe present a kinematic study of young stars in Messier 16 (M16) using the Gaia Data Release 3 and high-resolution spectra. A total of 345 stars are selected as genuine members using the published lists of X-ray sources, infrared sources, and early-type ...
Beomdu Lim +6 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source