Results 111 to 120 of about 300,825 (275)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2009 [abridged] The First Stars in the Universe form out of pristine primordial gas clouds that have been radiatively cooled to a few hundreds of degrees Kelvin either via molecular or atomic (Lyman-Alpha) hydrogen lines.
Bromm +55 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Low-mass Population III Star Formation due to the HD Cooling Induced by Weak Lyman–Werner Radiation
The Astrophysical JournalLyman–Werner (LW) radiation photodissociating molecular hydrogen (H _2 ) influences the thermal and dynamical evolution of the Population III (Pop III) star-forming gas cloud.
Sho Nishijima +2 more
doaj +1 more source
Population III Wolf-Rayet Stars in the CAK Regime
, 2007 Wolf-Rayet (WR) stars near solar metallicity are believed to be driven by radiation pressure on the UV spectral lines of metal ions. As the metallicity decreases so does the line opacity, therefore the mass-loss rate.
Onifer, A. J.
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
AEOS: Star-by-star Cosmological Simulations of Early Chemical Enrichment and Galaxy Formation
The Astrophysical JournalThe A eos project introduces a series of high-resolution cosmological simulations that model star-by-star chemical enrichment and galaxy formation in the early Universe, achieving 1 pc resolution.
Kaley Brauer +9 more
doaj +1 more source
Chemical Yields from the First Stars
, 1999 We examine the dependence of stellar yields on the metallicity Z of the stellar population. This effect may be important for the very first chemical enrichment from Population III stars, at very low Z.
Portinari, L.
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source