Results 111 to 120 of about 7,510,284 (318)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Prognosis of myelodysplasic patients: non‐parametric multiple regression analysis of populations stratified by mean corpuscular volume and marrow myeloblast number [PDF]

, 2002
G. B. Tennant, Ala Al-Sabah, Alan K. Burnett   +2 more
openalex   +1 more source

Novel efficient estimators of finite population mean in simple random sampling

Scientific African
This study presents a methodological advancement in survey sampling, focusing on the development of efficient estimators for the finite population mean under Simple Random Sampling without Replacement (SRSWOR).
Khazan Sher, Muhammad Iqbal, Hameed Ali, Soofia Iftikhar, Maggie Aphane, Ahmed Audu   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

APPENDIX I: COEFFICIENTS ( a _i AND b _i ) OF THE BEST ESTIMATES OF THE MEAN ( μ ) AND STANDARD DEVIATION ( σ ) IN CENSORED SAMPLES UP TO n = 20 FROM A NORMAL POPULATION [PDF]

, 2020
Elsayed A. Elsayed
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Enhancing the Mean Ratio Estimators for Estimating Population Mean Using Non-Conventional Location Parameters

Revista Colombiana de Estadística
Conventional measures of location are commonly used to develop ratio estimators. However, in this article, we attempt to use some non-conventional location measures.
MUHAMMAD ABID, NASIR ABBAS, HAFIZ ZAFAR NAZIR, ZHENGYAN LIN   +3 more
doaj  

Developing Improved Predictive Estimator for Finite Population Mean Using Auxiliary Information [PDF]

Statistika: Statistics and Economy Journal, 2015
The present paper deals with the estimation of population mean using predictive method of estimation utilizing auxiliary information. In this paper, we have proposed improved ratio cum product type predictive estimators to estimate the population mean ...
Subhash Kumar Yadav, Sant Sharan Mishra
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Dual Use of Auxiliary Information for Estimating the Finite Population Mean under the Stratified Random Sampling Scheme [PDF]

, 2021
Sohaib Ahmad, Sardar Hussain, Muhammad Aamir, Uzma Yasmeen, Javid Shabbir, Zubair Ahmad   +5 more
openalex   +1 more source