Results 61 to 70 of about 39,580 (190)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission

Parasites & Vectors, 2014
Background The freshwater snail Biomphalaria acts as the intermediate host of Schistosoma mansoni, a globally important human parasite. Understanding the population structure of intermediate host species can elucidate transmission dynamics and assist in ...
Claire J Standley, Sara L Goodacre, Christopher M Wade, J Russell Stothard   +3 more
doaj   +1 more source

Spatial Genetic Structure of the Tallgrass Prairie Grass Dichanthelium oligosanthes (Scribner's panicum)

Oklahoma Native Plant Record, 2011
The spatial genetic structure within plant populations and genetic differentiation among populations can vary in strength due to the forces of natural selection, gene flow and genetic drift.
Molly J. Parkhurst, Andrew Doust, Margarita Mauro-Herrera, Janette A. Steets, Jeffrey M. Byrnes   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Large carpenter bees show high dispersal in a tropical semi‐arid region susceptible to desertification

Ecology and Evolution
Desertification is a major threat to biodiversity in arid areas of the world, partly because many organisms in these regions already exist at or near the limits of their movement and physiology.
Sandara N. R. Brasil, Francisca Soares Araujo, Alan Brelsford, Christiana M. A. Faria, Lorenzo R. S. Zanette, S. Hollis Woodard   +5 more
doaj   +1 more source

Seedling dispersion and population structure of rosewood (Aniba rosaeodora Ducke) in Ucayali, Peru [PDF]

Acta Amazonica
Aniba rosaeodora is a valuable species of the Amazon, being extensively logged to extract linalool - a secondary metabolite that fixes cosmetic perfumes, which has led to its overexploitation and near extinction.
Jorge M. REVILLA-CHÁVEZ, Lyanna H. SÁENZ-RAMÍREZ, Antony C. GONZALES-ALVARADO, Alex J. ALVAREZ-GARCÍA, Jorge A. MORI-VÁSQUEZ, Alexandre M. SEBBENN   +5 more
doaj   +1 more source

Genetic structure of chimpanzee populations

PLoS Genetics, 2005
Little is known about the history and population structure of our closest living relatives, the chimpanzees, in part because of an extremely poor fossil record. To address this, we report the largest genetic study of the chimpanzees to date, examining 310 microsatellites in 84 common chimpanzees and bonobos. We infer three common chimpanzee populations,
Becquet, Celine, Patterson, Nick, Stone, Anne C, Przeworski, Molly, Reich, David   +4 more
openaire   +5 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source