Results 221 to 230 of about 7,148,896 (300)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genetic diversity of Schima superba based on physiological traits and SSR markers. [PDF]

PLoS One
Liu J, Shen W, Tan Z, Zhong Y.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cryptic Diversity and Genetic Variation in a Korean Endemic Freshwater Fish, the Korean Dark Chub (<i>Zacco koreanus</i>) Compared With Its Relative <i>Zacco temminckii</i>. [PDF]

Ecol Evol
Kim YR, Jang JE, Choi HK, Hwang SY, Kim JY, So S, Lee HJ.   +6 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The genomic impact of population connectivity and decline in Africa's elephants. [PDF]

Nat Commun
Pečnerová P, Ishida Y, Garcia-Erill G, Bertola LD, Santander CG, Liu X, Brüniche-Olsen A, Khan A, Hennelly LM, Balboa RF, Lin L, Rasmussen MS, Wang X, Schubert M, Al-Chaer A, Urbaniak S, Nobuta K, Treadup S, Viaud-Martinez KA, de Flamingh A, Malhi RS, Bird S, Ting N, Watsa M, Tchamba MN, Bourgeois S, Thouless C, Douglas-Hamilton I, Wittemyer G, Van Coeverden de Groot PJ, Muwanika VB, Masembe C, Georgiadis NJ, Hvilsom C, Heller R, Siegismund HR, Roca AL.   +36 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Phylogeography and Genetic Diversity of <i>Rana kukunoris</i> on the Northeast Qinghai-Xizang Plateau: Insights from Mitochondrial Cytochrome b Gene. [PDF]

Animals (Basel)
Zhang F, Dong B, Zhao Y, Wang W, He Y, Zhang X.   +5 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source