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Efficacy of a novel antigen-decorated adenoviral vaccine platform against porcine respiratory coronavirus infection in a large natural host

Wongborphid S, Briggs EJ, Russell RA, Chowdhury S, Vats A, Charlton BG, Rose LM, D'Agostino R, Bowman LAH, Rollier C, Hatton CF, Sadeyen J, Iqbal M, Moorhouse E, Cayol T, Bickerton E, Munir D, Salguero FJ, Paudyal B, Keep S, Biswas S, Dicks MDJ, Tchilian E.   +22 more
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Cell-surface glycans act as attachment factors for porcine hemagglutinating encephalomyelitis virus

Veterinary Microbiology, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a neurotropic coronavirus and highly pathogenic in veterinary clinic. Spike (S) protein of PHEV interplays with host components to cross the plasma membrane of target cells, but characterization of its functional receptors is limited.
Shiyu Hu, Kui Zhao, Yungang Lan, Junchao Shi, Jiyu Guan, Huijun Lu, Feng Gao, Haihua Feng, Wenqi He, Zi Li   +9 more
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Porcine Encephalomyelitis Caused by Hemagglutinating Encephalomyelitis Virus

Journal of the American Veterinary Medical Association, 1976
SUMMARY Six epizootics of encephalomyelitis in suckling pigs in Minnesota were attributed to infection with hemagglutinating encephalomyelitis virus. The disease occurred in 74 litters of pigs and was characterized by sudden onset of tremors, inappetence, weakness, ataxia, and hyperesthesia, with high morbidity and case fatality rate.
R E, Werdin, D K, Sorensen, W C, Stewart
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Antiviral effect of lysosomotropic disaccharide trehalose on porcine hemagglutinating encephalomyelitis virus, a highly neurotropic betacoronavirus

Virology, 2022
Many members of the genus Betacoronavirus are neurotropic viruses that frequently cause serious harm to humans or animals, including highly neurotropic porcine hemagglutinating encephalomyelitis virus (PHEV). Nevertheless, very few approved treatments exist to combat these viruses. Lysosomotropic trehalose, a widely used, nontoxic, natural disaccharide
Xiaomin, Ai, Wenqi, He, Xinran, Wang, Zhenzhen, Wang, Gaili, Wang, Hujun, Lu, Siyuan, Qin, Zi, Li, Jiyu, Guan, Kui, Zhao, Deguang, Song, Feng, Gao, Yungang, Lan   +12 more
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Development of an indirect ELISA based on soluble antigen produced from virus-infected cells for detection of porcine hemagglutinating encephalomyelitis virus

Journal of Virological Methods, 2021
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the genus Betacoronavirus and is the etiologic agent of encephalomyelitis or vomiting and wasting disease in neonatal pigs. Although there are only a few epidemiological studies that document the seroprevalence of PHEV infection, there are reports of sporadic outbreaks, including ...
Chau Thi Huyen Trang, Makoto Nakanishi, Hideki Hayashidani, Takahide Taniguchi   +3 more
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