DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action [PDF]
npj VaccinesPorcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, causes fatal neurological disease in piglets, yet no licensed vaccines exist.
Huabo Yu +12 more
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Development of a triplex crystal digital RT-PCR for the detection of PHEV, PRV, and CSFV [PDF]
Frontiers in Veterinary SciencePorcine hemagglutinating encephalomyelitis virus (PHEV), porcine pseudorabies virus (PRV), and classical swine fever virus (CSFV) are currently prevalent worldwide and cause similar neurological symptoms in infected pigs.
Kaichuang Shi +9 more
doaj +2 more sources
Complete genome sequence of a novel porcine hemagglutinating encephalomyelitis virus strain identified in South Korea. [PDF]
Arch Virol, 2022 Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the subgenus Embecovirus of the genus Betacoronavirus, and it is ubiquitously distributed in most pig-farming countries worldwide with low clinical incidence. Here, we report the full-length genome sequence and molecular characterization of a novel PHEV strain identified in ...
Kim Y, Lee KM, Jang G, Lee C.
europepmc +3 more sources
An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities. [PDF]
Mol Neurobiol, 2020 Lysosomes are involved in pathogenesis of a variety of neurodegenerative diseases and play a large role in neurodegenerative disorders caused by virus infection. However, whether virus-infected cells or animals can be used as experimental models of neurodegeneration in humans based on virus-related lysosomal dysfunction remain unclear.
Lan Y +10 more
europepmc +5 more sources
miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a. [PDF]
Arch Virol, 2020 Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic coronavirus that mainly invades the central nervous system (CNS) in piglets and causes vomiting and wasting disease. Emerging evidence suggests that PHEV alters microRNA (miRNA) expression profiles, and miRNA has also been postulated to be involved in its pathogenesis, but
Fan P +11 more
europepmc +4 more sources
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication. [PDF]
Front Cell Infect Microbiol, 2017 Autophagy is a basic biological metabolic process involving in intracellular membrane transport pathways that recycle cellular components and eliminate intracellular microorganisms within the lysosome. Autophagy also plays an important part in virus infection and propagation.
Ding N +8 more
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Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolism. [PDF]
Virol SinJia Q +7 more
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Pathogens, 2022 Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine ...
Ya-Mei Chen, Eric Burrough
doaj +1 more source
Genomic characterization and pathogenicity of a porcine hemagglutinating encephalomyelitis virus strain isolated in China. [PDF]
Virus Genes, 2018 Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the genus betacoronavirus within the family coronaviridae, which invades the central nervous system (CNS) via peripheral nervous system and causes encephalomyelitis or vomiting and wasting disease (VWD) in sucking piglets.
Shi J +8 more
europepmc +4 more sources
mSphere, 2021 The upper respiratory tract is the primary site of infection by porcine hemagglutinating encephalomyelitis virus (PHEV). In this study, primary porcine respiratory epithelial cells (PRECs) were cultured in an air-liquid interface (ALI) to differentiate ...
Rahul K. Nelli +2 more
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