Results 11 to 20 of about 20,148 (111)
Pore‐forming toxins of foodborne pathogens [PDF]
Comprehensive Reviews in Food Science and Food Safety, 2021 Abstract Pore‐forming toxins (PFTs) are water‐soluble molecules that have been identified as the most crucial virulence factors during bacterial pathogenesis. PFTs disrupt the host cell membrane to internalize or to deliver other bacterial or virulence factors for establishing infections.
Rajashri Banerji +3 more
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Enhanced SnapShot: Pore-Forming Toxins [PDF]
Cell, 2010 Enhanced SnapShots include features only possible online—animations, embedded captions, and dynamic visuals—all accessible by the click of a mouse. The goal of an Enhanced SnapShot is to provide everything currently available with the print SnapShot plus additional layers of information that are accessible through an easy to navigate interface.The ...
Mueller, Marcus, Ban, Nenad
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Pore-Forming Toxins Trigger the Purge [PDF]
Cell Host & Microbe, 2016 The intestinal epithelium responds to pathogens by coordinating microbial elimination with tissue repair, both required to survive an infection. In this issue of Cell Host & Microbe, Lee et al. (2016) discover a rapid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejection and enterocyte regrowth.
Alessandro, Bonfini, Nicolas, Buchon
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DEFENSE AND DEATH RESPONSES TO PORE FORMING TOXINS [PDF]
Biotechnology and Genetic Engineering Reviews, 2009 Pore forming toxins (PFT) are important virulence factors produced by bacteria to kill eukaryotic cells by forming holes in the cellular membrane. They represent a diverse group of proteins with a wide range of target cells. Although the amino acid sequence is not conserved among the different PFT, many of them share some aspects of their mechanism of ...
Angeles, Cancino-Rodezno +3 more
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Membrane Perforation by the Pore-Forming Toxin Pneumolysin [PDF]
Biophysical Journal, 2019 Significance Pneumolysin, a pore-forming toxin of Streptococcus pneumoniae , assembles into rings on cholesterol-containing membranes of host cells. β -hairpins form a barrel-shaped transmembrane
Martin Vögele +7 more
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Cellular and Molecular Life Sciences, 2002 Pore-forming toxins are widely distributed proteins which form lesions in biological membranes. In this review, bacterial pore-forming toxins are treated as a paradigm and discussed in terms of the structural principles on which they work. Then, a large family of bacterial toxins, the cholesterol-binding toxins, are analyzed in depth to provide an ...
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Host Glycan Recognition by a Pore Forming Toxin [PDF]
Structure, 2012 An exposed F-type lectin domain fused to the N-terminus of a cholesterol-dependent cytolysin scaffold allows Streptococcus mitis lectinolysin to cluster at fucose-rich sites on target cell membranes, thereby leading to increased pore-forming toxin activity.
Bouyain, Samuel, Geisbrecht, Brian V.
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Bacterial pore-forming toxins: The (w)hole story? [PDF]
Cellular and Molecular Life Sciences, 2007 Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat.
Gonzalez, M. +4 more
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Clostridial pore-forming toxins: Powerful virulence factors [PDF]
Anaerobe, 2014 Pore formation is a common mechanism of action for many bacterial toxins. More than one third of clostridial toxins are pore-forming toxins (PFTs) belonging to the β-PFT class. They are secreted as soluble monomers rich in β-strands, which recognize a specific receptor on target cells and assemble in oligomers.
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A biomimetic nanosponge that absorbs pore-forming toxins [PDF]
Nature Nanotechnology, 2013 Detoxification treatments such as toxin-targeted anti-virulence therapy offer ways to cleanse the body of virulence factors that are caused by bacterial infections, venomous injuries and biological weaponry. Because existing detoxification platforms such as antisera, monoclonal antibodies, small-molecule inhibitors and molecularly imprinted polymers ...
Hu, Che-Ming J. +4 more
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