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How Lipid Membranes Affect Pore Forming Toxin Activity
Accounts of Chemical Research, 2015Pore forming toxins (PFTs) evolved to permeate the plasma membrane of target cells. This is achieved in a multistep mechanism that usually involves binding of soluble protein monomer to the lipid membrane, oligomerization at the plane of the membrane, and insertion of part of the polypeptide chain across the lipid membrane to form a conductive channel.
Nejc, Rojko, Gregor, Anderluh
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Pore-Forming Bacterial Protein Toxins: An Overview
2001Among the ca. 325 protein toxins produced by gram-positive and gram-negative bacteria so far identified (Alouf 2000), at least 115 (35%) belong to the group of the so-called membrane-damaging toxins (MDTs). The most characteristic feature of these effectors is to damage or disrupt the cytoplasmic phospholipid bilayer membrane (7–9nm) of appropriate ...
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Activation induced by pore-forming bacterial toxins
Trends in Microbiology, 2001Pore-forming bacterial toxins are considered to be the principal virulence factors contributing to severe inflammatory diseases in humans and animals. The pore-forming toxins are released from Gram-negative bacteria as soluble monomeric proteins, which then assemble into oligomeric pores on their target cell membranes.
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The Family of Serratia Type Pore Forming Toxins
Current Protein & Peptide Science, 2005The Serratia marcescens hemolysin represents the prototype of a growing family of pore forming toxins. The available bacterial genome sequences reveal Serratia hemolysin homologues in additional species. However, only S. marcescens hemolysin has been studied in great molecular detail.
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Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Nature Reviews Microbiology, 2021Shannon L Kordus, Dana Borden Lacy
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Cellular Responses to Bacterial Pore-Forming Toxins
2011Pore-forming toxins (PFTs) represent the largest class of bacterial protein toxins and constitute major virulence factors produced by pathogenic bacteria during infection. Pore formation appears to be an ancient form of attack, which is also found in hydrozoans, plants and humans.
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Chemical targets to deactivate biological and chemical toxins using surfaces and fabrics
Nature Reviews Chemistry, 2021Luke A Parker +2 more
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Targeted Therapy of Cancer: New Prospects for Antibodies and Immunoconjugates
Ca-A Cancer Journal for Clinicians, 2006David M Goldenberg
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