Results 91 to 100 of about 18,671,976 (307)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Pore-Network Modeling of Polymer Flow in Porous Media
Computers and GeotechnicsNon-Newtonian fluid flows in porous media are critical in various subsurface and geotechnical engineering applications. However, accurately predicting such flows remains challenging due to complex fluid rheology and intricate pore structures. This study focuses on polymer fluids with shear-thinning rheology.
Si Suo +3 more
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Multi-scale modelling of gas flow in nanoscale pore space with fractures
Journal of Rock Mechanics and Geotechnical Engineering, 2020 In this work, a multi-scale pore network with fractures is developed against experimental data in a wide range of degrees of water saturation. The pore network is constructed based on the measured microstructure information at several length scales.
Qingrong Xiong +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
IMFN newsletter, vol. 6, April 2000 : a global future for the IMFN
, 2000 French version available in IDRC Digital Library: Bulletin du RIFM, numéro 6, avril 2000 : un avenir mondial pour le RIFMSpanish version available in IDRC Digital Library: Bolétein de la RED, vol.
International Model Forest Network
core +1 more source
Advances in Pore-Scale Simulation of Oil Reservoirs
Energies, 2018 At the high water cut stage, the residual oil in a reservoir becomes complex and dispersed. Moreover, it is challenging to achieve good predictions of the movement of oil and water in a reservoir according to the macroscopic models based on the statistic
Junwei Su +4 more
doaj +1 more source
Analysis of Water Agglomeration Inside the GDL Using a Pore-Network Model
, 2010 This article investigates the transient response of water motion inside the GDLs having different pore size distributions. A pore-network model is developed and applied to the problem.
Mehdi Shahraeeni, Mina Hoorfar
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
A Study to Investigate Fluid-Solid Interaction Effects on Fluid Flow in Micro Scales
Energies, 2018 Due to micro-nanopores in tight formation, fluid-solid interaction effects on fluid flow in porous media cannot be ignored. In this paper, a novel model which can characterize micro-fluid flow in micro scales is proposed.
Mingqiang Chen +3 more
doaj +1 more source