Results 111 to 120 of about 18,671,976 (307)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Szalontai, B., Ötvös, Ferenc, Benyhe, S., Boyett, M., Vágvölgyi, Csaba, Szûts, V., Papp, J.G., Dobrzynski, H.; id_orcid, Szüts, Viktória, Dézsi, László, Szalontai, Balázs, Dobrzynski, Halina, Zhang, Henggui, Benyhe, Sándor, Dézsi, L., Varró, András, Boyett, Marc, Vágvölgyi, C., Varró, A., Ötvös, F., Zhang, H., Papp, Gyula, Erdélyi, L., Erdélyi, Lajos   +23 more
core   +2 more sources

Pore Structure Analysis of Growing Media Using X-Ray Microcomputed Tomography

Applied Sciences
This study investigated the representative elementary volume (REV) for visible porosity in horticultural growing media (peat, commercial mixture, treated wood fibre/peat, pure wood fibre) using x-ray micro-computed tomography (µCT) with 2D and 3D image ...
Hadi Hamaaziz Muhammed, Ruediger Anlauf, Diemo Daum, Mayka Schmitt Rahner, Katrin Kuka   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A pore network modeling approach to bridge void ratio‐dependent soil water retention and unsaturated hydraulic conductivity curves

Engineering Reports
In geotechnical engineering, understanding the relationship between soil permeability and deformation is essential, particularly for applications like earth dams, where compaction‐induced permeability reduction is crucial for performance optimization. In
Rasoul Mirghafari, Seyed Sajjad Sajjadian, Ehsan Nikooee, Ghassem Habibagahi, Amir Raoof   +4 more
doaj   +1 more source

Simulation of Immiscible Counter-Current Flow in Porous Media Using a Modified Dynamic Pore Network Model

Applied Sciences
Accurately simulating immiscible counter-current flow is crucial for applications from geological CO2 storage to shale gas production, yet it remains a major challenge for conventional pore network models (PNMs), which are unable to handle the numerical ...
Yunbo Wei, Kouping Chen, Jichun Wu, Yun Yang, Zhi Dou   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Influence of inoculation on pore development of reconstructed soil layers in dump based on multifractal method

Meitan kexue jishu
Water resources are scarce in western China, where microbial reclamation technology is widely applied to mine dumps and preliminary ecological benefits are observed.
Zhongqing Li, Zengming Ke, Yinli Bi
doaj   +1 more source

Saturation Dependence of Non‐Fickian Transport in Porous Media

Water Resources Research, 2019
In two‐phase flow through porous media, the percolating pathways can be hydrodynamically split into the flowing and stagnant regions. The highly variable velocity field in the pore space filled by the carrier fluid leads to significant differences in the
Sharul Hasan, Vahid Joekar‐Niasar, Nikolaos K. Karadimitriou, Muhammad Sahimi   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source