Results 101 to 110 of about 18,671,976 (307)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Equivalence of the one-dimensional moisture diffusion model and the three dimensional pore network drying model

open access: yes, 2016
Equivalence of the one-dimensional moisture diffusion model and the three dimensional pore network drying ...
Prat, Marc   +3 more
core  

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

open access: yes, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Claire E Naylor   +34 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Multi-scale CT imaging technique characterization of volcanic rock reservoirs: a study case from the Changling fault depression of the southern Songliao Basin

open access: yesFrontiers in Earth Science
The Changling fault depression in the southern Songliao Basin hosts volcanic rock reservoirs with significant oil and gas potential, yet their complex pore structures require advanced characterization to optimize resource exploration. To address this, we
Jianfeng Zhu   +3 more
doaj   +1 more source

Pore network modelling for coal seams

open access: yes, 2017
Pore Network Modelling (PNM) is a well-established micro-scale numerical method for the prediction of permeability in reservoir rocks. We study the capabilities of this method for coal as a heterogeneous unconventional rock. The fracture structure of coal known as cleats is captured using high resolution micro-Computed Tomography (micro-CT) images at ...
openaire   +2 more sources

Pore-Scale Heterogeneities Improve the Degradation of a Self-Inhibiting Substrate: Insights from Reactive Transport Modeling

open access: yes, 2022
In situ bioremediation is a common remediation strategy for many groundwater contaminants. It was traditionally believed that (in the absence of mixing-limitations) a better in situ bioremediation is obtained in a more homogeneous medium where the even ...
Martin Elsner (1564447)   +3 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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