Results 121 to 130 of about 207,601 (314)

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Szalontai, B., Ötvös, Ferenc, Benyhe, S., Boyett, M., Vágvölgyi, Csaba, Szûts, V., Papp, J.G., Dobrzynski, H.; id_orcid, Szüts, Viktória, Dézsi, László, Szalontai, Balázs, Dobrzynski, Halina, Zhang, Henggui, Benyhe, Sándor, Dézsi, L., Varró, András, Boyett, Marc, Vágvölgyi, C., Varró, A., Ötvös, F., Zhang, H., Papp, Gyula, Erdélyi, L., Erdélyi, Lajos   +23 more
core  

Development of Pore Pressure in Cementitious Materials under Low Thermal Effects: Evidence from Optimization of Pore Structure by Incorporation of Fly Ash. [PDF]

Materials (Basel), 2023
Jiang W, Zhang D, Zheng X, Li W.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Wave-induced Pore Pressure Responses and Soil Liquefaction Around Pile Foundation

, 2011
A 3D FEM model is proposed and verified with existing experimental data for simulating wave-induced transient and residual pore pressure responses around a pile foundation.
杨兵, Zang J, 高福平, 李小均, Li, XJ (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China   +4 more
core  

Effects of an impermeable layer on pore pressure response to tsunami-like inundation. [PDF]

Proc Math Phys Eng Sci, 2022
Exton M, Yeh H.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Field Test of Excess Pore Water Pressure at Pile–Soil Interface Caused by PHC Pipe Pile Penetration Based on Silicon Piezoresistive Sensor

, 2020
Prestressed high-strength concrete (PHC) pipe pile with the static press-in method has been widely used in recent years. The generation and dissipation of excess pore water pressure at the pile–soil interface during pile jacking have an important ...
Zhang, Mingyi, Liu, Xueying, Xueying Liu, Suchun Yang, Yonghong Wang, Songkui Sang, Yang, Suchun, Sang, Songkui, Mingyi Zhang, Wang, Yonghong   +9 more
core   +1 more source

Distribution Relationship of Pore Pressure and Matrix Stress during Hydraulic Fracturing. [PDF]

ACS Omega, 2021
Zhao X, Huang B.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

New Models for Predicting Pore Pressure and Fracture Pressure while Drilling in Mixed Lithologies Using Artificial Neural Networks. [PDF]

ACS Omega, 2022
Khaled S, Soliman AA, Mohamed A, Gomaa S, Attia AM.   +4 more
europepmc   +1 more source