Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Derivation, validation, and prediction of loading-induced mineral apposition rates at endocortical and periosteal bone surfaces based on fluid velocity and pore pressure. [PDF]
Bone Rep, 2023 Singh S, Singh SJ, Prasad J.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
, 2014 A finite element model for the pore pressure responses under the action of combined waves and current is proposed and verified with the existing experimental data. In this numerical model, both transient and residual pore pressure responses are simulated
Gao FP(高福平), Wang YF(王意发)
core +2 more sources
Soil consolidation acoustic experiment and pore pressure prediction model establishment-taking the Yingqiong Basin as an example. [PDF]
Sci Rep, 2023 Han Z, Sun B, Cheng Y, Yan C.
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Development of Pore Pressure in Cementitious Materials under Low Thermal Effects: Evidence from Optimization of Pore Structure by Incorporation of Fly Ash. [PDF]
Materials (Basel), 2023 Jiang W, Zhang D, Zheng X, Li W.
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Soils and FoundationsA two-dimensional consolidation model for unsaturated–saturated soils under plane strain conditions is developed based on Fredlund’s and Terzaghi’s consolidation theories for unsaturated and saturated soils, respectively. Furthermore, an interfacial flow
Dansheng Yu +7 more
doaj +1 more source