From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Effects of Pore Pressure and Temperature Difference Variation on Borehole Stability
, 2013 Considering that drilling fluid filtration and the temperature difference between borehole wall rock and drilling fluid can cause the stress variation of the borehole wall.
Chi, AI, Yu, LIU, Yuwei, LI
core +1 more source
Observation and modeling of the suction pump effect during rapid dilatant slip [PDF]
, 2003 The temporary pressure drop observed during post-peak dilatant slip in axi-symmetric testing of a porous aeolian sandstone is modeled using a simple function of opening caused by sliding along the fault surface.
Rudnicki, J. W. +3 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Derivation, validation, and prediction of loading-induced mineral apposition rates at endocortical and periosteal bone surfaces based on fluid velocity and pore pressure. [PDF]
Bone Rep, 2023 Singh S, Singh SJ, Prasad J.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Mudstone porosity and clay fraction in overpressured basins [PDF]
, 2002 This thesis demonstrates the use of a mixture of standard and novel petrophysical techniques to estimate physical parameters of mudstone and explores the use of a generic, clay fraction-dependent compaction model in the context of pore pressure ...
Ecclestone-Brown, Paul
core
Soil consolidation acoustic experiment and pore pressure prediction model establishment-taking the Yingqiong Basin as an example. [PDF]
Sci Rep, 2023 Han Z, Sun B, Cheng Y, Yan C.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source