Results 51 to 60 of about 422,597 (347)

Numerical analysis of seepage–deformation in unsaturated soils [PDF]

, 2014
A coupled elastic–plastic finite element analysis based on simplified consolidation theory for unsaturated soils is used to investigate the coupling processes of water infiltration and deformation.
A Qin, AW Bishop, DG Fredlund, DV Griffiths, E Conte, E Garcia, EE Alonso, EL Liu, Enlong Liu, F Cai, F Stauffer, G Deng, Gang Deng, H Rahardjo, H Yang, H Yang, HA Basha, HA Basha, Hai-Sui Yu, HJ Morel-Seytoux, HJ Morel-Seytoux, Jianhai Zhang, JM Chen, LT Zhan, LZ Wu, MM Nezhad, N Khalili, RI Borja, RI Borja, RI Borja, RJ Bathurst, RW Lewis, SE Cho, SE Serrano, Siming He, TMH Le, W Ehlers, W Sun, X Song, ZJ Shen   +39 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Mechanical properties and energy evolution and the applicability of strength criteria of sandstone under hydro-mechanical coupling

Meitan xuebao, 2023
To explore the hydraulic coupling characteristics of rocks, triaxial compression tests on water-saturated sandstone under hydro-mechanical coupling were carried out using the MTS815 rock mechanics test system. The test confining pressures were 10, 20, 30
Yanlin ZHAO, Tao TAN, Chunyang ZHANG, Qiang LIU, Yingjie ZHANG, Lianhua WU   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Experimental investigation on dilatancy behavior of water-saturated sandstone

International Journal of Mining Science and Technology, 2018
It is important to study the dilatancy property of water-saturated rock for understanding the engineering behavior of loaded rock mass. This study carried out the uniaxial and triaxial compressive experiments on the water-saturated red sandstone ...
Jiangyu Wu, Meimei Feng, Bangyong Yu, Wenli Zhang, Xiaoyan Ni, Guansheng Han   +5 more
doaj   +1 more source

Stability Analysis of Shield Inclined Tunnel Faces under the Change Effect of Soil Heterogeneity and Pore Water with Buried Depth

Geofluids, 2022
The purpose of this work is to look at how soil heterogeneity and pore water pressure impact shield inclined tunnel excavation face stability as burial depth varies.
Hong Sun, Dao-bing Zhang, Hua-dong Yin, A-ping Hu   +3 more
doaj   +1 more source

Dissipated energy in undrained cyclic triaxial tests [PDF]

, 2015
Energy-based methods are an emerging tool for the evaluation of liquefaction potential. These methods relate excess pore water pressure build-up to seismic energy dissipated per unit volume.
Azeiteiro, RJN, Coelho, PALF, Grazina, JC, Taborda, DMG   +3 more
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source