Results 121 to 130 of about 12,287 (215)

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

The ropAe gene encodes a porin‐like protein involved in copper transit in Rhizobium etli CFN42

MicrobiologyOpen, 2018
Copper (Cu) is an essential micronutrient for all aerobic forms of life. Its oxidation states (Cu+/Cu2+) make this metal an important cofactor of enzymes catalyzing redox reactions in essential biological processes.
Antonio González‐Sánchez, Ciro A. Cubillas, Fabiola Miranda, Araceli Dávalos, Alejandro García‐de los Santos   +4 more
doaj   +1 more source

A Four‐Center Study on the Activity of Aztreonam and Aztreonam‐Avibactam Combination Against Clinical Isolates of Gram‐Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β‐Lactamases

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz, Hasan Cenk Mirza, Aylin Üsküdar Güçlü, Özlem Öğüç Şanlı, Özlem Kurt Azap, Banu Sancak, Elvan Hortaç İştar, Ahmet Başustaoğlu   +7 more
wiley   +1 more source

Genetic Characterization of Multidrug-Resistant Acinetobacter baumannii and Synergy Assessment of Antimicrobial Combinations

Antibiotics
Background/Objectives: A. baumannii is a prominent nosocomial pathogen due to its drug-resistant phenotype, representing a public health problem. In this study, the aim was to determine the effect of different antimicrobial combinations against selected ...
Aurora Luna-De-Alba, Samantha Flores-Treviño, Adrián Camacho-Ortiz, Juan Francisco Contreras-Cordero, Paola Bocanegra-Ibarias   +4 more
doaj   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, Volume 293, Issue 18, Page 5585-5599, September 2026.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Mind the Porins: Differential Effects of Porin Knockouts and Overexpression on Glucose and Xylose Uptake and Utilization in Pseudomonas putida

Microbial Biotechnology
Porins serve as the primary transport channels for substrate molecules across the outer membrane of Gram‐negative bacteria. Despite their potential to influence substrate uptake in microbial cell factories, porins are often overlooked in metabolic ...
Barbora Popelářová, Nicolas T. Wirth, Daniel C. Volke, Tibor Botka, Pablo I. Nikel, Pavel Dvořák   +5 more
doaj   +1 more source

Protein–Protein Interactions Between Peptidoglycan, Lipopolysaccharide, and Phospholipid Biosynthesis Enzymes in Escherichia coli

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
MurA, the first peptidoglycan biosynthesis enzyme, interacts with essential proteins involved in lipopolysaccharide and phospholipid biogenesis and is associated with the LapB interactome. Gram‐negative bacteria are protected by a three‐layered cell envelope and must tightly coordinate the biosynthesis of phospholipids (PL), peptidoglycan (PG) and ...
Lea‐Janina Tilg, Sophia Weber, Hannah Bille, Anna‐Maria Möller, Franz Narberhaus   +4 more
wiley   +1 more source

Detection of porins in Klebsiella pneumoniae isolates.

, 2013
Top part, immunodetection was carried out with antiserum directed against denatured OmpF porin; bottom part, immunodetection was carried out with antiserum directed against denatured OmpC porin.
Véronique Leflon-Guibout (333980), Latifa Noussair (374036), Frédéric Bert (374034), Jean-Philippe Lavigne (328610), Estelle Marcon (374033), Jean-Marie Pages (5653822), Marie-Hélène Nicolas-Chanoine (328618)   +6 more
core   +1 more source

Hyperproduction of fibrin and inefficacy of antithrombin III and alpha2 macroglobulin in the presence of bacterial porins.

, 2005
Bacterial porins enhance the thrombin activity upon chromogen substrate chromozym. Should porin-dependent enhancement of thrombin activity take place also upon fibrinogen in vivo, this might greatly increase the fibrin production which, in turn, might ...
LEPRETTI M., CAPASSO R., STIUSO, Paola, IOVENE, Maria Rosaria, DONNARUMMA, Giovanna, DI MICCO B., TUFANO M. A., DI MICCO P.   +7 more
core   +1 more source

Carbapenem-Resistant Klebsiella aerogenes Clinical Isolates from a Teaching Hospital in Southwestern China: Detailed Molecular Epidemiology, Resistance Determinants, Risk Factors and Clinical Outcomes

Infection and Drug Resistance, 2020
De-Yu Ma, 1,* Han-Yu Huang, 2,* Hua Zou, 1 Meng-Lu Wu, 1 Qiu-Xia Lin, 1 Bo Liu, 3 Shi-Feng Huang 1 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China ...
Ma DY, Huang HY, Zou H, Wu ML, Lin QX, Liu B, Huang SF   +6 more
doaj